Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463 2015
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group CTD_human Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. 24441527 2014
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group CTD_human Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells. 24792327 2014
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group CTD_human Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism. 23046578 2013
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 Biomarker group CTD_human Familial aggregation of parkinsonism in progressive supranuclear palsy. 19458322 2009
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group CTD_human These findings confirm that recessive mutations in PINK1 cause early-onset parkinsonism and expand the associated clinical phenotype. 15349871 2004
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group CTD_human This region contains a novel locus for autosomal recessive early-onset parkinsonism, PARK6. 11254447 2001
Entrez Id: 7054
Gene Symbol: TH
TH
0.700 Biomarker group CTD_human Four novel mutations in the tyrosine hydroxylase gene in patients with infantile parkinsonism. 11246459 2000
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 Biomarker group CTD_human Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene. 10802785 2000
Entrez Id: 7054
Gene Symbol: TH
TH
0.700 Biomarker group CTD_human Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene. 8817341 1996
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.600 Biomarker group CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463 2015
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.600 Biomarker group CTD_human Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism. 23046578 2013
Entrez Id: 2668
Gene Symbol: GDNF
GDNF
0.530 Therapeutic group CTD_human Behavioral improvement and dopamine release in a Parkinsonian rat model. 12213621 2002
Entrez Id: 2668
Gene Symbol: GDNF
GDNF
0.530 Therapeutic group CTD_human Thus, combined GDNF-Sinemet treatment could be of therapeutic value in treating parkinsonism, by producing a greater functional response and by mitigating adverse responses to Sinemet treatment. 9266731 1997
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions. 27324791 2017
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism. 26687234 2016
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human Protective effect of Geraniol on the transgenic Drosophila model of Parkinson's disease. 27026137 2016
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463 2015
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.500 Biomarker group CTD_human A recurrent mutation in PARK2 is associated with familial lung cancer. 25640678 2015
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.500 Biomarker group CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463 2015
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.500 Therapeutic group CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463 2015
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.500 Therapeutic group CTD_human A recurrent mutation in PARK2 is associated with familial lung cancer. 25640678 2015
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model. 26075822 2015
Entrez Id: 2629
Gene Symbol: GBA
GBA
0.500 Biomarker group CTD_human Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies. 25881142 2015
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats. 23295396 2013