Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.010 Biomarker disease BEFREE <i>BRCA1/2</i> Functional Loss Defines a Targetable Subset in Leiomyosarcoma. 30541756 2019
Entrez Id: 9968
Gene Symbol: MED12
MED12
0.050 GeneticVariation disease BEFREE Leiomyosarcoma specimens were examined for exon 2 MED12 mutations to evaluate the frequency of MED12 mutated leiomyosarcomas. 27889101 2017
Entrez Id: 5324
Gene Symbol: PLAG1
PLAG1
0.010 AlteredExpression disease BEFREE PLAG1 over-expression was also found in three of nine mesenchymal tumors, i.e., in two uterine leiomyomas and one leiomyosarcoma. 10029085 1999
Entrez Id: 6590
Gene Symbol: SLPI
SLPI
0.010 Biomarker disease BEFREE ALK1 and/or p80 reactivity was observed in a cytoplasmic pattern in IMT (4/10; 40%), malignant peripheral nerve sheath tumor (4/10; 40%), rhabdomyosarcoma (6/31; 19%), leiomyosarcoma (1/10; 10%), and malignant fibrous histiocytoma (1/11; 9%). 12218210 2002
Entrez Id: 94
Gene Symbol: ACVRL1
ACVRL1
0.010 Biomarker disease BEFREE ALK1 and/or p80 reactivity was observed in a cytoplasmic pattern in IMT (4/10; 40%), malignant peripheral nerve sheath tumor (4/10; 40%), rhabdomyosarcoma (6/31; 19%), leiomyosarcoma (1/10; 10%), and malignant fibrous histiocytoma (1/11; 9%). 12218210 2002
Entrez Id: 6591
Gene Symbol: SNAI2
SNAI2
0.020 AlteredExpression disease BEFREE SNAI2 mRNA was expressed in placenta, melanocyte, embryonic stem (ES) cells, leiomyosarcoma, neuroblastoma, and glioblastoma.SNAI3 mRNA was expressed in B cells. 16142376 2005
Entrez Id: 1435
Gene Symbol: CSF1
CSF1
0.010 AlteredExpression disease BEFREE CSF1 expression in nongynecological leiomyosarcoma is associated with increased tumor angiogenesis. 21854753 2011
Entrez Id: 6323
Gene Symbol: SCN1A
SCN1A
0.010 Biomarker disease BEFREE NAC1 gene knockdown inhibited cell growth and induced apoptosis in SKN, a leiomyosarcoma cell line, and in OMC-9, an endometrial stromal sarcoma cell line, both of which overexpress NAC1. 22993327 2012
Entrez Id: 112939
Gene Symbol: NACC1
NACC1
0.010 Biomarker disease BEFREE NAC1 gene knockdown inhibited cell growth and induced apoptosis in SKN, a leiomyosarcoma cell line, and in OMC-9, an endometrial stromal sarcoma cell line, both of which overexpress NAC1. 22993327 2012
Entrez Id: 9968
Gene Symbol: MED12
MED12
0.050 GeneticVariation disease BEFREE MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma. 24390224 2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.030 AlteredExpression disease BEFREE MYC protein levels were elevated in both murine leiomyosarcoma cell lines. 26555296 2015
Entrez Id: 11274
Gene Symbol: USP18
USP18
0.010 Biomarker disease BEFREE USP18 null mice and the derived cell lines represent clinically-relevant models of leiomyosarcoma and can provide insights into both leiomyosarcoma biology and therapy. 26555296 2015
Entrez Id: 7153
Gene Symbol: TOP2A
TOP2A
0.010 AlteredExpression disease BEFREE TOP2A copy number and TOP2A expression in uterine benign smooth muscle tumours and leiomyosarcoma. 26994023 2016
Entrez Id: 1024
Gene Symbol: CDK8
CDK8
0.010 AlteredExpression disease BEFREE CDK8 Expression in Extrauterine Leiomyosarcoma Correlates With Tumor Stage and Progression. 27389556 2018
Entrez Id: 406943
Gene Symbol: MIR152
MIR152
0.010 AlteredExpression disease BEFREE miR-152 down-regulation is associated with MET up-regulation in leiomyosarcoma and undifferentiated pleomorphic sarcoma. 27900663 2017
Entrez Id: 10403
Gene Symbol: NDC80
NDC80
0.010 AlteredExpression disease BEFREE NDC80 mRNA was abnormally overexpressed not only in OS, but also in other sarcomas including liposarcoma, myxofibrosarcoma, and leiomyosarcoma. 28537682 2017
Entrez Id: 91807
Gene Symbol: MYLK3
MYLK3
0.010 Biomarker disease BEFREE MLCK and phosphorylated MLC are potential prognostic indicators of leiomyosarcoma. 28618653 2017
Entrez Id: 85366
Gene Symbol: MYLK2
MYLK2
0.010 Biomarker disease BEFREE MLCK and phosphorylated MLC are potential prognostic indicators of leiomyosarcoma. 28618653 2017
Entrez Id: 9961
Gene Symbol: MVP
MVP
0.010 Biomarker disease BEFREE MVP immunohistochemistry is a useful adjunct in distinguishing leiomyosarcoma from leiomyoma and leiomyoma with bizarre nuclei. 29307622 2018
Entrez Id: 22800
Gene Symbol: RRAS2
RRAS2
0.020 GeneticVariation disease BEFREE TC21 is a ras family member that shares close homology to H-, K- and N-ras, and activating mutations have been found in ovarian carcinoma and leiomyosarcoma cell lines. 9703274 1998
Entrez Id: 633
Gene Symbol: BGN
BGN
0.010 AlteredExpression disease BEFREE Biglycan gene expression in the human leiomyosarcoma cell line SK-UT-1. Basal and protein kinase A-induced transcription involves binding of Sp1-like/Sp3 proteins in the proximal promoter region. 9786935 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE A high rate of point mutations in TP53 was observed uniquely in leiomyosarcoma, osteosarcoma, and MFH. 21159888 2011
Entrez Id: 22800
Gene Symbol: RRAS2
RRAS2
0.020 GeneticVariation disease BEFREE A novel insertional mutation in the TC21 gene activates its transforming activity in a human leiomyosarcoma cell line. 7478545 1995
Entrez Id: 55733
Gene Symbol: HHAT
HHAT
0.020 Biomarker disease BEFREE A plasmid containing a human calponin h1 complementary DNA and a bacterial neomycin-resistance gene was transfected into the human leiomyosarcoma cell lines SKN and SK-LMS-1 by electroporation. 10328110 1999
Entrez Id: 8626
Gene Symbol: TP63
TP63
0.060 Biomarker disease BEFREE A plasmid containing a human calponin h1 complementary DNA and a bacterial neomycin-resistance gene was transfected into the human leiomyosarcoma cell lines SKN and SK-LMS-1 by electroporation. 10328110 1999