However, the associations between several previously reported miR-SNPs, including miR-196a2 rs11614913, miR-146a rs2910164, miR-34b/c rs4938723, and miR-423rs6505162 and the susceptibility of esophageal squamous cell carcinoma (ESCC) remain controversial.
Herein, tests were done on an Iranian cohort to evaluate the association of miRNA-related polymorphisms in miR-423 (rs6505162) and peroxisomal biogenesis factor 6 (PEX6) (rs1129186 within a miR-149-5p-binding site) with the risk of ESCC risk.
A case-control study in 248 Kazakh patients with ESCC and 300 frequency matched control subjects was carried out to examine the potential association of six miRNA (miR-100 rs1834306, miR-34b/c rs4938723, miR-375 rs6715345, miR-146a rs2910164, miR-423rs6505162 and miR-373 rs12983273) polymorphisms with risk of ESCC.
These findings indicated that functional polymorphisms hsa-miR-34b/c rs4938723 T>C and hsa-miR-423rs6505162 C>A might alter individual susceptibility to ESCC.