Source: CURATED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.700 Biomarker disease CTD_human Prognosis of esophageal squamous cell carcinoma in patients positive for human epidermal growth factor receptor family can be improved by initial chemotherapy with docetaxel, fluorouracil, and cisplatin. 21947696 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.700 CausalMutation disease CGI
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.600 Biomarker disease CTD_human Genetic landscape of esophageal squamous cell carcinoma. 25151357 2014
Entrez Id: 51741
Gene Symbol: WWOX
WWOX 		0.530 Biomarker disease CTD_human Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. 25526675 2015
Entrez Id: 51741
Gene Symbol: WWOX
WWOX 		0.530 SusceptibilityMutation disease ORPHANET The hypermethylation of promoter and exon1 of WWOX was found to be occurred in dysplastic tissues and the methylation frequency of WWOX in ESCC tumor tissues was significantly higher than that in corresponding normal tissues and was associated with UGIC family history. 22213016 2013
Entrez Id: 51741
Gene Symbol: WWOX
WWOX 		0.530 SusceptibilityMutation disease ORPHANET Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma. 11956080 2002
Entrez Id: 7403
Gene Symbol: KDM6A
KDM6A 		0.520 Biomarker disease CTD_human Genetic landscape of esophageal squamous cell carcinoma. 25151357 2014
Entrez Id: 7403
Gene Symbol: KDM6A
KDM6A 		0.520 CausalMutation disease CGI
Entrez Id: 7403
Gene Symbol: KDM6A
KDM6A 		0.520 GenomicAlterations disease CGI
Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1 		0.500 Biomarker disease CTD_human PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. 20729853 2010
Entrez Id: 51196
Gene Symbol: PLCE1
PLCE1 		0.500 Biomarker disease CTD_human A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34). 20729852 2010
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.500 CausalMutation disease CGI
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1 		0.400 Biomarker disease CTD_human A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. 25538231 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		0.400 Biomarker disease CTD_human Genetic landscape of esophageal squamous cell carcinoma. 25151357 2014
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.400 Biomarker disease CTD_human Genetic landscape of esophageal squamous cell carcinoma. 25151357 2014
Entrez Id: 340061
Gene Symbol: STING1
STING1 		0.400 Biomarker disease CTD_human Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. 25129146 2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.400 Biomarker disease CTD_human Genetic landscape of esophageal squamous cell carcinoma. 25151357 2014
Entrez Id: 482
Gene Symbol: ATP1B2
ATP1B2 		0.400 Biomarker disease CTD_human Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. 25129146 2014
Entrez Id: 4255
Gene Symbol: MGMT
MGMT 		0.400 Biomarker disease CTD_human Promoter methylation of MGMT gene in serum of patients with esophageal squamous cell carcinoma in North East India. 25520135 2014
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2 		0.400 Biomarker disease CTD_human We confirmed the known association of the ALDH2 locus on 12q24 to ESCC, and a joint analysis showed that drinkers with both of the ADH1B and ALDH2 risk alleles had a fourfold increased risk for ESCC compared to drinkers without these risk alleles. 22960999 2012
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B 		0.400 Biomarker disease CTD_human We confirmed the known association of the ALDH2 locus on 12q24 to ESCC, and a joint analysis showed that drinkers with both of the ADH1B and ALDH2 risk alleles had a fourfold increased risk for ESCC compared to drinkers without these risk alleles. 22960999 2012
Entrez Id: 811
Gene Symbol: CALR
CALR 		0.400 Biomarker disease CTD_human Using proteomic approach to identify tumor-associated proteins as biomarkers in human esophageal squamous cell carcinoma. 21517111 2011
Entrez Id: 113278
Gene Symbol: SLC52A3
SLC52A3 		0.400 Biomarker disease CTD_human C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA. 20729853 2010
Entrez Id: 6657
Gene Symbol: SOX2
SOX2 		0.400 Biomarker disease CTD_human These characteristics identify SOX2 as a lineage-survival oncogene in lung and esophageal SCC. 19801978 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker disease CTD_human COX-2 mRNA expression is a frequent phenomenon in human ESCC tissue samples and plays an important role in the carcinogenesis of ESCC. 18197933 2008