×
Entrez Id:
2064
Gene Symbol:
ERBB2
ERBB2
0.140
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
2064
Gene Symbol:
ERBB2
ERBB2
0.140
AlteredExpression
disease
BEFREE
AKT, EGFR, C-ErbB-2 , and C-kit expression in uterine carcinosarcoma .
23896716
2013
×
Entrez Id:
2064
Gene Symbol:
ERBB2
ERBB2
0.140
AlteredExpression
disease
BEFREE
Demonstration of HER-2/neu overexpression and amplification in uterine carcinosarcoma may represent the first rationale step for further investigations.
16445668
2006
×
Entrez Id:
2064
Gene Symbol:
ERBB2
ERBB2
0.140
AlteredExpression
disease
BEFREE
We describe HER-2/neu overexpression and her-2/neu oncogene amplification in a case of uterine carcinosarcoma occurring in a 46-year-old women who had undergone mastectomy and a 2-year postoperative treatment with tamoxifen for invasive breast cancer.
15901136
2005
×
Entrez Id:
2064
Gene Symbol:
ERBB2
ERBB2
0.140
GeneticVariation
disease
BEFREE
The current results suggest absence of ERBB-2 overexpression in uterine leiomyosarcoma, uterine adenosarcoma, and endometrial stromal sarcoma, whereas the ERBB-2 gene might have a biologic role in uterine carcinosarcoma and undifferentiated uterine sarcomas.
15581967
2004
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.120
GeneticVariation
disease
BEFREE
In addition to TP53 , other recurrently mutated genes harboring putative driver or loss-of-function mutations included PTEN, FBXW7, FGFR2, KRAS, PIK3CA and CTNNB1, genes known to be involved in UCS .
30194005
2018
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.120
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.120
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.120
GeneticVariation
disease
BEFREE
Molecular alterations of PIK3CA in uterine carcinosarcoma , clear cell, and serous tumors.
25078343
2014
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.120
GeneticVariation
disease
BEFREE
The expression of AKT, epithelial growth factor receptor, C-Kit, and C-ErbB-2 were studied by immunohistochemistry and exons 9 and 20 of PIK3CA gene were sequences in a cohort of 37 UCS , including 23 early-stage (I and II) and 14 late-stage (III and IV) tumors.
23896716
2013
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.120
Biomarker
disease
BEFREE
DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis.
16810312
2006
×
Entrez Id:
55294
Gene Symbol:
FBXW7
FBXW7
0.110
Biomarker
disease
BEFREE
Genomic analysis showed that most tumors spontaneously acquired <i>Trp53</i> mutations, pointing to a triad of pathways (p53, PI3K, and Fbxw7 ) as the critical combination underpinning uterine carcinosarcoma , and to Fbxw7 as a key driver of this enigmatic endometrial cancer type.
31772025
2019
×
Entrez Id:
5426
Gene Symbol:
POLE
POLE
0.110
Biomarker
disease
BEFREE
Tumor Mutational Burden Guides Therapy in a Treatment Refractory <i>POLE -</i>Mutant Uterine Carcinosarcoma .
29386312
2018
×
Entrez Id:
5426
Gene Symbol:
POLE
POLE
0.110
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
55294
Gene Symbol:
FBXW7
FBXW7
0.110
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5295
Gene Symbol:
PIK3R1
PIK3R1
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5518
Gene Symbol:
PPP2R1A
PPP2R1A
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
2263
Gene Symbol:
FGFR2
FGFR2
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
7307
Gene Symbol:
U2AF1
U2AF1
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
3265
Gene Symbol:
HRAS
HRAS
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
2065
Gene Symbol:
ERBB3
ERBB3
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
80316
Gene Symbol:
PPP1R2C
PPP1R2C
0.050
Biomarker
disease
BEFREE
This is a secondary analysis of a previous multicenter retrospective study examining 906 women with stage I-IV UCS who underwent primary hysterectomy.
31196490
2019
×
Entrez Id:
80316
Gene Symbol:
PPP1R2C
PPP1R2C
0.050
Biomarker
disease
BEFREE
This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I-IV UCS who underwent primary hysterectomy.
29971677
2018
×
Entrez Id:
80316
Gene Symbol:
PPP1R2C
PPP1R2C
0.050
Biomarker
disease
BEFREE
This is a secondary analysis of multicenter retrospective study examining women with stages I-IV UCS who underwent primary surgery.
30217299
2018