Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.310 GeneticVariation disease BEFREE AZD6244 was evaluated against two JPA xenografts, BT-35 (wild-type BRAF) and BT-40 (mutant [V600E] BRAF). 20806365 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.240 GeneticVariation disease BEFREE This is the first report of a p53 mutation in grade I juvenile pilocytic astrocytomas. 8108140 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.240 GeneticVariation disease BEFREE High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. 10416986 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.240 GeneticVariation disease BEFREE Unusual findings include: TP53 mutation in a juvenile pilocytic astrocytoma; TP53 and PTEN mutations in a de novo glioblastoma, a gliosarcoma with identical mutations in gliomatous and sarcomatous components, and an infratentorial anaplastic astrocytoma with an earlier supratentorial grade II astrocytoma bearing the same TP53 mutation but not the PTEN mutation or loss of heterozygosity (LOH) of 10q23. 11355303 2001
Entrez Id: 3234
Gene Symbol: HOXD8
HOXD8 		0.010 GeneticVariation disease BEFREE Results indicate that in ATRTs, medulloblastomas, and JPAs, the HOTAIR and HOXC genes are highly expressed; however, HOXD8-10 genes are not silenced. 25085602 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.010 GeneticVariation disease BEFREE Unusual findings include: TP53 mutation in a juvenile pilocytic astrocytoma; TP53 and PTEN mutations in a de novo glioblastoma, a gliosarcoma with identical mutations in gliomatous and sarcomatous components, and an infratentorial anaplastic astrocytoma with an earlier supratentorial grade II astrocytoma bearing the same TP53 mutation but not the PTEN mutation or loss of heterozygosity (LOH) of 10q23. 11355303 2001
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.310 Biomarker disease CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572 2013
Entrez Id: 4314
Gene Symbol: MMP3
MMP3 		0.300 Biomarker disease CTD_human Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. 20188714 2010
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1 		0.300 Biomarker disease CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572 2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.300 Biomarker disease CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572 2013
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.300 Biomarker disease CTD_human Expression of estrogen receptors, androgen receptor and steroid receptor coactivator-3 is negatively correlated to the differentiation of astrocytic tumors. 24680642 2014
Entrez Id: 23462
Gene Symbol: HEY1
HEY1 		0.300 Biomarker disease CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729 2010
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11 		0.300 Biomarker disease CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572 2013
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.300 Biomarker disease CTD_human Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. 15341671 2004
Entrez Id: 23493
Gene Symbol: HEY2
HEY2 		0.300 Biomarker disease CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729 2010
Entrez Id: 4763
Gene Symbol: NF1
NF1 		0.300 Biomarker disease CTD_human Bioluminescent approaches for measuring tumor growth in a mouse model of neurofibromatosis. 20176786 2010
Entrez Id: 8202
Gene Symbol: NCOA3
NCOA3 		0.300 Biomarker disease CTD_human Expression of estrogen receptors, androgen receptor and steroid receptor coactivator-3 is negatively correlated to the differentiation of astrocytic tumors. 24680642 2014
Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2 		0.300 Biomarker disease CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572 2013
Entrez Id: 3082
Gene Symbol: HGF
HGF 		0.300 Biomarker disease CTD_human Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells. 11223164 2001
Entrez Id: 9113
Gene Symbol: LATS1
LATS1 		0.300 Biomarker disease CTD_human Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. 17049657 2006
Entrez Id: 10397
Gene Symbol: NDRG1
NDRG1 		0.300 Biomarker disease CTD_human Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. 15341671 2004
Entrez Id: 57670
Gene Symbol: KIAA1549
KIAA1549 		0.300 Biomarker disease CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.300 Biomarker disease CTD_human Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. 20188714 2010
Entrez Id: 10683
Gene Symbol: DLL3
DLL3 		0.300 Biomarker disease CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729 2010
Entrez Id: 4853
Gene Symbol: NOTCH2
NOTCH2 		0.300 Biomarker disease CTD_human Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. 21127729 2010