Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1301
Gene Symbol: COL11A1
COL11A1 		0.030 AlteredExpression disease BEFREE COL11A1, which encodes the alpha 1 chain of type XI collagen, was highly expressed in IVD, but its expression was decreased in the IVD of patients with LDH. 17999364 2007
Entrez Id: 27178
Gene Symbol: IL37
IL37 		0.010 Biomarker disease BEFREE Interleukin-23 may contribute to the pathogenesis of lumbar disc herniation through the IL-23/IL-17 pathway. 26774625 2016
Entrez Id: 407008
Gene Symbol: MIR223
MIR223 		0.010 Biomarker disease BEFREE MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation. 28460630 2017
Entrez Id: 7421
Gene Symbol: VDR
VDR 		0.030 GeneticVariation disease BEFREE VDR Fok I polymorphisms did not have any significant association with LDH in Sri Lankan ethnicity. 30356314 2018
Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1 		0.010 Biomarker disease BEFREE AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model. 30817738 2019
Entrez Id: 353
Gene Symbol: APRT
APRT 		0.010 Biomarker disease BEFREE AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model. 30817738 2019
Entrez Id: 2006
Gene Symbol: ELN
ELN 		0.010 Biomarker disease BEFREE Elastin degradation and fibrosis of the LF in the DLSS patients is more severe compared with the SLSS and LDH patients. 31638980 2019
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN 		0.010 GeneticVariation disease BEFREE Association of interleukin-1 receptor antagonist gene polymorphism with response to conservative treatment of lumbar herniated nucleus pulposus. 20581747 2010
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		0.010 GeneticVariation disease BEFREE Associations of Caspase-3 gene polymorphism with lumbar disc herniation. 27847097 2016
Entrez Id: 3479
Gene Symbol: IGF1
IGF1 		0.010 Biomarker disease BEFREE BACKGROUND The expression and mechanism of IL-1, IL-2, IL-8, BMP, FGF1, and IGF-1 in Sprague-Dawley (SD) rats with lumbar disc herniation were investigated. 30716059 2019
Entrez Id: 268
Gene Symbol: AMH
AMH 		0.010 Biomarker disease BEFREE Both PELD and MIS-TLIF, as treatments for lumbar disc herniation with biradicular symptoms, showed favorable clinical outcomes. 30055359 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.020 AlteredExpression disease BEFREE By contrast, upregulation of interleukin-2 (IL-2), IL-6, IL-8 and tumor necrosis factor-α (TNF-α) expression was observed in patients with LDH, according to an enzyme-linked immunosorbent assay. 25816023 2015
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.020 GeneticVariation disease BEFREE Carriers of the CC genotype of the IL-1β (+3953 T/C) SNP were more frequent among LDH patients suggesting some potential role of the IL-1β SNP on LDH pathogenesis. 21837414 2011
Entrez Id: 55016
Gene Symbol: MARCHF1
MARCHF1 		0.010 Biomarker disease BEFREE Chart review was conducted for patients undergoing surgery for lumbar disc herniation between January 1, 2000 and March 1, 2018. 31185292 2019
Entrez Id: 3554
Gene Symbol: IL1R1
IL1R1 		0.010 GeneticVariation disease BEFREE CONCLUSIONS This study demonstrated that genetic variants in the IL1R1 genes were associated with LDH risk in the Han population of northwestern China. 31104063 2019
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6 		0.010 Biomarker disease BEFREE Condoliase (chondroitin sulfate ABC endolyase), a glycosaminoglycan-degrading enzyme, was approved by the drug regulatory authority in Japan as a newer intradiscal therapy for LDH after clinical studies conducted in Japan demonstrated efficacy and safety for patients with LDH. 30740609 2019
Entrez Id: 4312
Gene Symbol: MMP1
MMP1 		0.020 GeneticVariation disease BEFREE Effects of MMP-1 and MMP-3 gene polymorphisms on gene expression and protein level in lumbar disc herniation. 27706715 2016
Entrez Id: 4314
Gene Symbol: MMP3
MMP3 		0.010 GeneticVariation disease BEFREE Effects of MMP-1 and MMP-3 gene polymorphisms on gene expression and protein level in lumbar disc herniation. 27706715 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.020 Biomarker disease BEFREE Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation. 30716059 2019
Entrez Id: 3552
Gene Symbol: IL1A
IL1A 		0.010 Biomarker disease BEFREE Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation. 30716059 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2 		0.010 Biomarker disease BEFREE Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation. 30716059 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8 		0.010 Biomarker disease BEFREE Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation. 30716059 2019
Entrez Id: 2246
Gene Symbol: FGF1
FGF1 		0.010 Biomarker disease BEFREE Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation. 30716059 2019
Entrez Id: 9507
Gene Symbol: ADAMTS4
ADAMTS4 		0.020 AlteredExpression disease BEFREE Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation. 16741450 2006
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.010 GeneticVariation disease BEFREE For the first time, our results provide evidence on polymorphism of BDNF / BDNFOS gene associated with LDH risk in Chinese Han population. 30143695 2018