Gene: PIK3CD ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway. 20657188 2010
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE Activation of the PI3K/Akt pathway is associated with incomplete metabolic response in cervical cancer. 22235101 2012
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 AlteredExpression disease BEFREE Combination of valproic acid and ATRA restores RARβ2 expression and induces differentiation in cervical cancer through the PI3K/Akt pathway. 22229477 2012
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE These results suggest that targeted inhibition of PI3K/AKT may improve response to chemoradiation in cervical cancer. 23899375 2013
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE CD38 was correlated with dysregulation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway in cervical cancer tissues in vitro. 25310288 2014
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE Taken together, our data suggest that anti-VEGFa treatment in cervical cancer may inhibit both tumor cell growth and invasion through PI3k/Akt/mTor signaling pathway. 25135429 2014
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 AlteredExpression disease BEFREE Additionally, treatment with butein significantly increased reactive oxygen species (ROS) generation and reduced the phosphorylation of PI3K, AKT and mTOR expression, which contributes to the inhibition of the tumor growth of cervical cancer and reduction of oxidative stress. 25962638 2015
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 GeneticVariation disease BEFREE Here we demonstrate that PTEN destabilization is induced by EGFR- or oncogenic PI3K mutation-mediated AKT activation in cervical cancer. 26183061 2015
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is principally involved in the homeostatic maintenance of PI3K/Akt signaling and PTEN has been identified to play an important role in the occurrence and development of cervical cancer. 25738254 2015
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 GeneticVariation disease BEFREE Seventy percent of patients with endometrial cancer and more than 50% of patients with breast, prostate, anal, hepatocellular, colorectal, and cervical cancer exhibited alterations in at least 1 PI3K pathway gene and/or gene product. 27388585 2016
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE Tumor-Suppressor Gene NBPF1 Inhibits Invasion and PI3K/mTOR Signaling in Cervical Cancer Cells. 26802646 2016
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for Therapy. 28475243 2017
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE FOXC1 promotes proliferation and epithelial-mesenchymal transition in cervical carcinoma through the PI3K-AKT signal pathway. 28386355 2017
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE Aberrant activation of the phosphoinositide-3-kinase (PI3K) pathway frequently occurs in solid tumors, including cervical cancer. 28036259 2017
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE Our study suggests that R7 is a promising chemotherapeutic agent for the treatment of cervical cancer and other PI3K/PTEN/Akt/mTOR signaling-associated tumors. 29312623 2017
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE Tobacco Exposure Enhances Human Papillomavirus 16 Oncogene Expression via EGFR/PI3K/Akt/c-Jun Signaling Pathway in Cervical Cancer Cells. 30619121 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE let-7i-5p, miR-181a-2-3p and EGF/PI3K/SOX2 axis coordinate to maintain cancer stem cell population in cervical cancer. 29777148 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 GeneticVariation disease BEFREE Clinical outcomes and differential effects of PI3K pathway mutation in obese versus non-obese patients with cervical cancer. 29423104 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE We suggest that SKA3 overexpression contributes to CC cell growth and migration by promoting cell cycle progression and activating the PI3K-Akt signaling pathway, which may provide potential novel therapeutic targets for CC treatment. 30459531 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE microRNA-383 suppresses the PI3K-AKT-MTOR signaling pathway to inhibit development of cervical cancer via down-regulating PARP2. 29236322 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE MicroRNA‑433 inhibits cell growth and induces apoptosis in human cervical cancer through PI3K/AKT signaling by targeting FAK. 30272334 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE Knockdown of hnRNP A2/B1 inhibits cell proliferation, invasion and cell cycle triggering apoptosis in cervical cancer via PI3K/AKT signaling pathway. 29328485 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE miR-338 modulates proliferation and autophagy by PI3K/AKT/mTOR signaling pathway in cervical cancer. 29898430 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE Fibulin-3 promoted cervical cancer cell invasive capabilities by eliciting EMT and activating the PI3K-Akt-mTOR signal transduction pathway. 30006571 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.100 Biomarker disease BEFREE Baicalein inhibits cervical cancer progression via downregulating long noncoding RNA BDLNR and its downstream PI3K/Akt pathway. 29175387 2018