Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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|
0.260 | GeneticVariation | disease | BEFREE | DNA sequencing, performed in 84% of cases, revealed that TP53 mutations were most frequent in gemistocytic astrocytomas (88%), followed by fibrillary astrocytomas (53%) and oligoastrocytomas (44%), but were infrequent (13%) in oligodendrogliomas. | 15118874 | 2004 | ||||
|
0.260 | GeneticVariation | disease | BEFREE | LOH 1p/19q typically occurred in tumors without TP53 mutations and were most frequent in oligodendrogliomas (69%), followed by oligoastrocytomas (45%), but were rare in fibrillary astrocytomas (7%) and absent in gemistocytic astrocytomas. | 15977639 | 2005 | ||||
|
0.260 | GeneticVariation | disease | BEFREE | In this study, gemistocytes and non-gemistocytic neoplastic cells were separated by laser-assisted microdissection from six gemistocytic astrocytomas carrying TP53 mutations. | 11699553 | 2001 | ||||
|
0.260 | GeneticVariation | disease | BEFREE | These results indicate that p53 mutations are a genetic hallmark of gemistocytic astrocytomas, whilst PTEN mutations are absent in low-grade and rare in anaplastic gemistocytic astrocytomas. | 9650746 | 1998 | ||||
|
0.260 | GeneticVariation | disease | BEFREE | Whether the high frequency of p53 mutations contributes to the more aggressive behavior of gemistocytic astrocytomas, however, remains unclear. | 11152345 | 2001 | ||||
|
0.260 | Biomarker | disease | CTD_mouse | Bioluminescent approaches for measuring tumor growth in a mouse model of neurofibromatosis. | 20176786 | 2010 | ||||
|
0.010 | Biomarker | disease | BEFREE | Cytoplasmic immunoreactivity against VEGF was observed in high-grade and in gemistocytic astrocytomas, but not in conventional grade 2 tumors. | 12960698 | 2003 | ||||
|
0.010 | GeneticVariation | disease | BEFREE | The poor prognosis in GAs could be attributed both to the high frequency of p53 mutations and low p27 LI. | 16614946 | 2006 |