Patients with age-related cataract, regular corneal astigmatism less than 1.25 diopters (D) and a clinically significant vitreomacular pathology (epiretinal membrane [ERM], macular hole, or vitreomacular traction [VMT] syndrome) who had combined phacovitrectomy with internal limiting membrane peeling were enrolled.
Predicting postoperative astigmatism based on preoperative results is not possible; however, in eyes with a high difference between TCA3 and TCA5, a reduction in corneal astigmatism after DMEK is likely.
Single marker-based association tests for corneal astigmatism identified four genome-wide significant loci (P < 5 × 10<sup>-8</sup>) near the genes ZC3H11B (1q41), LINC00340 (6p22.3), HERC2/OCA2 (15q13.1) and NPLOC4/TSPAN10 (17q25.3).
Gene-based analysis identified three novel candidate genes for corneal astigmatism in Europeans-claudin-7 (<i>CLDN7</i>), acid phosphatase 2, lysosomal (<i>ACP2</i>), and TNF alpha-induced protein 8 like 3 (<i>TNFAIP8L3</i>).
Highest correlation of corneal astigmatism was noted with corneal area encroached by pterygium (ρ = 0.540 for LOA and 0.553 for HOA) and distance from pupillary center (ρ = 0.531 for LOA and 0.564 for HOA).
We describe a 9-year-old girl with BCS1, already blind in one eye following trauma, who had a 14 mm diameter corneoscleral onlay graft to her contralateral eye to reduce gross irregular corneal astigmatism and potentially to reduce further risk from accidental injury.
Gene-based analysis identified three novel candidate genes for corneal astigmatism in Europeans-claudin-7 (<i>CLDN7</i>), acid phosphatase 2, lysosomal (<i>ACP2</i>), and TNF alpha-induced protein 8 like 3 (<i>TNFAIP8L3</i>).
Single marker-based association tests for corneal astigmatism identified four genome-wide significant loci (P < 5 × 10<sup>-8</sup>) near the genes ZC3H11B (1q41), LINC00340 (6p22.3), HERC2/OCA2 (15q13.1) and NPLOC4/TSPAN10 (17q25.3).
Gene-based analysis identified three novel candidate genes for corneal astigmatism in Europeans-claudin-7 (<i>CLDN7</i>), acid phosphatase 2, lysosomal (<i>ACP2</i>), and TNF alpha-induced protein 8 like 3 (<i>TNFAIP8L3</i>).
We describe a 9-year-old girl with BCS1, already blind in one eye following trauma, who had a 14 mm diameter corneoscleral onlay graft to her contralateral eye to reduce gross irregular corneal astigmatism and potentially to reduce further risk from accidental injury.
The polar value method was performed with anterior and posterior corneal astigmatism measured with Scheimpflug camera combined with Placido corneal topography (Sirius, CSO) and refractive astigmatism preoperatively and 1 month, 3 months, and 6 months postoperatively.