Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10111
Gene Symbol: RAD50
RAD50 		0.340 Biomarker disease CLINGEN Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility. 14684699 2003
Entrez Id: 10111
Gene Symbol: RAD50
RAD50 		0.340 Biomarker disease CLINGEN RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability. 16474176 2006
Entrez Id: 4683
Gene Symbol: NBN
NBN 		0.340 Biomarker disease CLINGEN Significant association between Nijmegen breakage syndrome 1 657del5 polymorphism and breast cancer risk. 23765759 2013
Entrez Id: 10111
Gene Symbol: RAD50
RAD50 		0.340 Biomarker disease CLINGEN To evaluate the contribution of RAD50 to familial breast cancer, we screened the whole coding region for mutations in 435 UK and 46 Finnish familial breast cancer cases. 16385572 2006
Entrez Id: 84464
Gene Symbol: SLX4
SLX4 		0.330 Biomarker disease CLINGEN Next-generation sequencing in familial breast cancer patients from Lebanon. 28202063 2017
Entrez Id: 84464
Gene Symbol: SLX4
SLX4 		0.330 Biomarker disease CLINGEN Although this is the first study that describes a truncating SLX4 mutation in breast cancer patients, our data indicate that germline mutations in SLX4 are very rare and are unlikely to make a significant contribution to familial breast cancer. 22911665 2013
Entrez Id: 84464
Gene Symbol: SLX4
SLX4 		0.330 Biomarker disease CLINGEN Low prevalence of SLX4 loss-of-function mutations in non-BRCA1/2 breast and/or ovarian cancer families. 23211700 2013
Entrez Id: 84464
Gene Symbol: SLX4
SLX4 		0.330 Biomarker disease CLINGEN Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. 24726326 2014
Entrez Id: 84464
Gene Symbol: SLX4
SLX4 		0.330 Biomarker disease CLINGEN Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment. 24733792 2014
Entrez Id: 84464
Gene Symbol: SLX4
SLX4 		0.330 Biomarker disease CLINGEN Assessment of SLX4 Mutations in Hereditary Breast Cancers. 23840564 2013
Entrez Id: 84464
Gene Symbol: SLX4
SLX4 		0.330 Biomarker disease CLINGEN Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia. 21240276 2011
Entrez Id: 84464
Gene Symbol: SLX4
SLX4 		0.330 Biomarker disease CLINGEN SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. 21240277 2011
Entrez Id: 5965
Gene Symbol: RECQL
RECQL 		0.320 Biomarker disease CLINGEN RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. 17158923 2007
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH 		0.320 Biomarker disease CLINGEN
Entrez Id: 4361
Gene Symbol: MRE11
MRE11 		0.320 Biomarker disease CLINGEN Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer. 28073364 2017
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.320 Biomarker disease CLINGEN The extracolonic cancer spectrum in females with the common 'South African' hMLH1 c.C1528T mutation. 18049911 2008
Entrez Id: 5965
Gene Symbol: RECQL
RECQL 		0.320 Biomarker disease CLINGEN Germline RECQL mutations are associated with breast cancer susceptibility. 25915596 2015
Entrez Id: 4361
Gene Symbol: MRE11
MRE11 		0.320 Biomarker disease CLINGEN The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. 9651580 1998
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.320 Biomarker disease CLINGEN Germline RAD51C mutations confer susceptibility to ovarian cancer. 22538716 2012
Entrez Id: 5965
Gene Symbol: RECQL
RECQL 		0.320 Biomarker disease CLINGEN Our findings suggest that RECQL is a potential breast cancer susceptibility gene and that mutations in this gene contribute to familial breast cancer development. 25945795 2015
Entrez Id: 5965
Gene Symbol: RECQL
RECQL 		0.320 Biomarker disease CLINGEN Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. 18074021 2007
Entrez Id: 4361
Gene Symbol: MRE11
MRE11 		0.320 Biomarker disease CLINGEN Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas. 14511253 2003
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.320 Biomarker disease CLINGEN Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964 2010
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.320 Biomarker disease CLINGEN Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer. 28418444 2017
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.320 Biomarker disease CLINGEN Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. 22167183 2012