Odds ratios (ORs) with 95% confidence intervals (CIs) were determined as measures of the strength of association between polymorphisms of XRCC1 and pancreatic cancer risk.
In conclusion, we found that XRCC1Arg399Gln genetic variations are associated with pancreatic cancer development, whereas the XRCC1Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.
Results from this study indicate that the c.1517G>C genetic variant of the XRCC1 gene is significantly associated with PC susceptibility in the Chinese population.
In the subgroup analysis based on ethnicity, there was no statistically significant association between XRCC1rs1799782 genetic polymorphism and pancreatic cancer risk in Asians/Caucasians under all genetic models (all P values > 0.05).
However, the XRCC1(194) polymorphism had a significant interaction with the APE1(148) (p=0.005) or MGMT(84) polymorphism (p=0.02) in modifying the risk of pancreatic cancer.