rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This study examined the main and interactive effect of 9 single-nucleotide polymorphisms (SNPs) (Arg194Trp, Arg280His, Arg399Gln, c.1254C>T, c.1517G>C, c.1471G>A, C310T, 539del542, and T1915C) of XRCC1 in contribution to pancreatic cancer (PC).
|
26418909 |
2016 |
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, we found that XRCC1 Arg399Gln genetic variations are associated with pancreatic cancer development, whereas the XRCC1 Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.
|
27323136 |
2016 |
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In the subgroup analysis based on ethnicity, there was no statistically significant association between XRCC1 rs1799782 genetic polymorphism and pancreatic cancer risk in Asians/Caucasians under all genetic models (all P values > 0.05).
|
24435745 |
2014 |
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Yet only one polymorphism, XRCC1 Arg194Trp, appears to be involved in smoking-related cancers and in early onset pancreatic cancer.
|
17397816 |
2007 |
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
rs25487
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, we found that XRCC1 Arg399Gln genetic variations are associated with pa</span>ncreatic cancer development, whereas the XRCC1 Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.
|
27323136 |
2016 |
rs25487
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Therefore, the meta-analysis suggests that XRCC1 rs25487 polymorphism is associated with pancreatic cancer</span> risk in Asians.
|
23807675 |
2013 |
rs25487
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We observed that the minor allele of rs25487 in XRCC1 was significantly associated with PC risk in the per-allele model (odds ratio = 1.29, CI = 1.01-1.65; trend P = 0.043).
|
22850545 |
2012 |
rs25487
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results from our stratified analysis based on Hardy-Weinberg equilibrium (HWE) showed that there was a robust significant association between Arg280His polymorphism and pancreatic cancer risk (allelic model, OR 0.743, 95% CI 0.576-0.958, P = 0.022; heterozygous model, OR 0.701, 95% CI 0.525-0.936, P = 0.016; dominant model, OR 0.710, 95% CI 0.537-0.939, P = 0.016).
|
29285737 |
2019 |
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, we found that XRCC1 Arg399Gln genetic variations are associated with pancreatic cancer development, whereas the XRCC1 Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.
|
27323136 |
2016 |
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A tendency of association between Arg280His and PC was also detected in the dominant model (OR, 0.70; 95% CI, 0.48-1.00).
|
26418909 |
2016 |
rs139599857
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results from this study indicate that the c.1517G>C genetic variant of the XRCC1 gene is significantly associated with PC susceptibility in the Chinese population.
|
25036351 |
2014 |