Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6016
Gene Symbol: RIT1
RIT1 		0.200 Biomarker disease MGD New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis. 30898653 2019
Entrez Id: 8216
Gene Symbol: LZTR1
LZTR1 		0.200 Biomarker disease MGD Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. 30442762 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.200 Biomarker disease MGD K-RasV14I recapitulates Noonan syndrome in mice. 25359213 2014
Entrez Id: 5894
Gene Symbol: RAF1
RAF1 		0.200 Biomarker disease MGD Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. 22826437 2012
Entrez Id: 5894
Gene Symbol: RAF1
RAF1 		0.200 Biomarker disease MGD MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation. 21339642 2011
Entrez Id: 6654
Gene Symbol: SOS1
SOS1 		0.200 Biomarker disease MGD Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. 21041952 2010
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11 		0.200 Biomarker disease MGD Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. 15273746 2004
Entrez Id: 55835
Gene Symbol: CENPJ
CENPJ 		0.200 Biomarker disease MGD
Entrez Id: 545
Gene Symbol: ATR
ATR 		0.200 Biomarker disease MGD
Entrez Id: 80254
Gene Symbol: CEP63
CEP63 		0.200 Biomarker disease MGD