Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP 		0.300 Biomarker disease CTD_human Inorganic mercury within motor neurons does not cause the TDP-43 changes seen in sporadic ALS. 21167262 2011
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis. 21867702 2011
Entrez Id: 10133
Gene Symbol: OPTN
OPTN 		0.300 Biomarker disease CTD_human Processing of optineurin in neuronal cells. 21059646 2011
Entrez Id: 6529
Gene Symbol: SLC6A1
SLC6A1 		0.300 Biomarker disease CTD_human In vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis. 20132478 2010
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons. 20132483 2010
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R. 20515040 2010
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG 		0.300 Therapeutic disease CTD_human From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis. 20348957 2010
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis. 20348957 2010
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Rapid one-step purification of native dimeric ALS-associated human Cu/Zn superoxide dismutase from transgenic rat tissues. 19929749 2010
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Transcriptional profiling in the lumbar spinal cord of a mouse model of amyotrophic lateral sclerosis: a role for wild-type superoxide dismutase 1 in sporadic disease? 20177826 2010
Entrez Id: 23025
Gene Symbol: UNC13A
UNC13A 		0.300 Biomarker disease CTD_human Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. 19734901 2009
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop. 19635794 2009
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells. 18233996 2008
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP 		0.300 Biomarker disease CTD_human TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. 18372902 2008
Entrez Id: 1804
Gene Symbol: DPP6
DPP6 		0.300 Biomarker disease CTD_human Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. 18084291 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.300 Biomarker disease CTD_human Transcription factor p53 in degenerating spinal cords. 17434459 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. 17496168 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model. 17319283 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis. 17097207 2007
Entrez Id: 2936
Gene Symbol: GSR
GSR 		0.300 Biomarker disease CTD_human Alterations in anti-oxidative defence enzymes in erythrocytes from sporadic amyotrophic lateral sclerosis (SALS) and familial ALS patients. 16681429 2006
Entrez Id: 25978
Gene Symbol: CHMP2B
CHMP2B 		0.300 Biomarker disease CTD_human ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). 16807408 2006
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1 		0.300 Biomarker disease CTD_human Activity and expression of glutathione S-transferase pi in patients with amyotrophic lateral sclerosis. 16109392 2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3. 16495328 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.300 Biomarker disease CTD_human Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. 15816863 2005
Entrez Id: 5321
Gene Symbol: PLA2G4A
PLA2G4A 		0.300 Biomarker disease CTD_human Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. 15816863 2005