| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.030 | GeneticVariation | disease | BEFREE | Mutations in the aryl hydrocarbon receptor-interacting protein (<i>AIP</i>) gene are associated with pituitary adenoma, acromegaly and gigantism. | 28634279 | 2017 | ||||
|
0.030 | Biomarker | disease | BEFREE | Increased Population Risk of AIP-Related Acromegaly and Gigantism in Ireland. | 27650164 | 2017 | ||||
|
0.030 | GeneticVariation | disease | BEFREE | Mutations of the aryl hydrocarbon receptor interacting protein (AIP) have been associated with familial isolated pituitary adenomas predisposing to young-onset acromegaly and gigantism. | 23300914 | 2012 | ||||
|
0.020 | Biomarker | disease | BEFREE | Determination of serum levels of GH and IGF-I is crucial for the diagnosis and treatment of GH deficiency and disorders related to GH excess such as acromegaly and pituitary gigantism. | 30378780 | 2018 | ||||
|
0.020 | Biomarker | disease | BEFREE | Measurement of the levels of growth hormone (GH) and its related factor insulin-like growth factor I (IGF-I) is essential for the diagnosis and treatment of GH deficiency (GHD) and conditions related to excess GH such as acromegaly and pituitary gigantism. | 28516748 | 2017 | ||||
|
0.020 | Biomarker | disease | BEFREE | Measurement of the levels of growth hormone (GH) and its related factor insulin-like growth factor I (IGF-I) is essential for the diagnosis and treatment of GH deficiency (GHD) and conditions related to excess GH such as acromegaly and pituitary gigantism. | 28516748 | 2017 | ||||
|
0.020 | Biomarker | disease | BEFREE | Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. | 25470569 | 2014 | ||||
|
0.010 | GeneticVariation | disease | BEFREE | Besides GNAS gene mutations, the molecular pathogenesis of somatotroph adenomas responsible for gigantism and acromegaly remains elusive. | 30376114 | 2019 | ||||
|
0.010 | GeneticVariation | disease | BEFREE | Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. | 25470569 | 2014 |