|
KIAA0319
|
0.100 |
Biomarker
|
disease |
BEFREE |
The KIAA0319 gene is one of the most robust dyslexia susceptibility factors but its function remains poorly understood.
|
30950042 |
2019 |
|
KIAA0319
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that unstable representations of auditory and visual stimuli in auditory and other reading-related neocortical regions are present in a subset of children with dyslexia and support the link between the gene KIAA0319 and the auditory neural variability across children with or without dyslexia.
|
29894888 |
2018 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we analyzed DNA methylation in the KIAA0319 (a gene involved in dyslexia and ciliogenesis) promoter region to investigate whether epigenetic markers of language lateralization can be identified in non-neuronal tissue.
|
28958754 |
2018 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined 4 SNPs located on genes previously associated to dyslexia (KIAA0319, DCDC2, DYX1C1 and FOXP2) and 3 SNPs within genes related to ADHD (COMT, MAOA and DBH) in a cohort of Spanish children (N = 2078) that met the criteria of having one, both or none of these disorders (dyslexia and ADHD).
|
30379906 |
2018 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling.
|
28334068 |
2017 |
|
KIAA0319
|
0.100 |
Biomarker
|
disease |
BEFREE |
Current data provide the first evidence that the dyslexia-associated gene KIAA0319 can alter brainstem responses and impair phoneme processing in the auditory brainstem.
|
28182973 |
2017 |
|
KIAA0319
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several candidate genes have been proposed to be implicated in dyslexia susceptibility, such as DYX1C1, ROBO1, KIAA0319, and DCDC2.
|
28074887 |
2017 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We used a custom-by-design 48-Plex SNPscan Kit to genotype 18 single-nucleotide polymorphisms (SNPs) of KIAA0319 in a group of 196 children with dyslexia and 196 controls of Uyghur descent aged 8-12 years.
|
27098879 |
2016 |
|
KIAA0319
|
0.100 |
Biomarker
|
disease |
BEFREE |
DYX1C1, DCDC2, and KIAA0319 are three of the most replicated dyslexia candidate genes (DCGs).
|
27451412 |
2016 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The brain regions were partly overlapping with the previously reported region influenced by polymorphisms in the dyslexia susceptibility genes DYX1C1 and KIAA0319.
|
26400686 |
2015 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings expand the literature showing genetic factors (e.g., DYX2) contributing to multiple related, yet distinct neurocognitive domains (e.g., dyslexia, language impairment, and SSD).
|
25778907 |
2015 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As expected, there were associations with known RD risk genes KIAA0319 and DCDC2.
|
24509779 |
2014 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Results indicate that KIAA0319 is not associated with Chinese children with dyslexia but a haplotype consisting of rs2760157 and rs807507 SNPs were significantly associated with an onset detection test, a measure of phonological awareness (pnominal = 6.85 10-5 and pcorrected = 0.0029).
|
25015435 |
2014 |
|
KIAA0319
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression patterns of speech disorder- (FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed.
|
24769279 |
2014 |
|
KIAA0319
|
0.100 |
Biomarker
|
disease |
BEFREE |
Three genes, DYX1C1, DCDC2, and KIAA0319, have been previously associated with dyslexia, neuronal migration, and ciliary function.
|
25339756 |
2014 |
|
KIAA0319
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also provide evidence that BV677278 interacts nonadditively with KIAA0319, an RD-associated gene, to adversely affect several reading and cognitive phenotypes.
|
23746548 |
2013 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population.
|
23677054 |
2013 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data do not support a role of the DCDC2/KIAA0319 locus in influencing dyslexia as a categorical trait.
|
24301907 |
2013 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results suggested that the 931C > T variant in KIAA0319, but not the -3G > A in DYX1C1, was significantly associated with the risk of dyslexia.
|
23065966 |
2012 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability.
|
22750057 |
2012 |
|
KIAA0319
|
0.100 |
Biomarker
|
disease |
BEFREE |
The novel findings included a set of genes (DCDC2, DYX1C1, KIAA0319) related to a neurological disease dyslexia suggesting their potential involvement in ciliary functions.
|
22558177 |
2012 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319.
|
22326444 |
2012 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, healthy subjects bearing the KIAA0319/TTRAP/THEM2 variants previously identified as enhancing the risk of dyslexia showed a reduced left-hemispheric asymmetry of the STS.
|
22262880 |
2012 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KIAA0319-like, located near the dyslexia susceptibility locus, DYX8 in chromosome 1p34.3, has been suggested as a positional candidate for developmental dyslexia due to its homology with another gene, KIAA0319 which has been strongly established as a candidate gene for developmental dyslexia.
|
20697954 |
2011 |
|
KIAA0319
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the KIAA0319 5' region as a possible contributor to dyslexia.
|
21207242 |
2011 |