Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5653
Gene Symbol: KLK6
KLK6 		0.010 AlteredExpression disease BEFREE Kallikrein 6 was down-regulated in malignant glioma, but this differential expression did not have an impact on patient prognosis. 19661345 2009
Entrez Id: 4255
Gene Symbol: MGMT
MGMT 		0.400 PosttranslationalModification disease BEFREE MGMT promoter methylation in malignant gliomas: ready for personalized medicine? 19997073 2010
Entrez Id: 208
Gene Symbol: AKT2
AKT2 		0.260 Biomarker disease BEFREE Akt2 may play a critical role in the development of gliomas and present a potential therapeutic target for malignant gliomas. 20116920 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.100 GeneticVariation disease BEFREE Epidermal growth factor receptor (EGFR) gene amplification is the most common genetic alteration in high-grade glioma, and approximately 50% of EGFR-amplified tumors also harbor a constitutively active mutant form of the receptor, DeltaEGFR. 20133782 2010
Entrez Id: 208
Gene Symbol: AKT2
AKT2 		0.260 Biomarker disease BEFREE Akt2 and Akt3 play a pivotal role in malignant gliomas. 20167810 2010
Entrez Id: 406954
Gene Symbol: MIR181A2
MIR181A2 		0.010 Biomarker disease BEFREE MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2. 20204284 2010
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.050 AlteredExpression disease BEFREE β-Catenin overexpression in malignant glioma and its role in proliferation and apoptosis in glioblastma cells. 20300972 2011
Entrez Id: 11230
Gene Symbol: PRAF2
PRAF2 		0.010 AlteredExpression disease BEFREE PRAF2 mRNA and protein expression was elevated in several cancer tissues with highest levels in malignant glioma. 20412121 2010
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA 		0.050 Biomarker disease BEFREE PDGFRA was the predominant target of focal amplification in childhood HGG, including diffuse intrinsic pontine gliomas, and gene expression analyses supported an important role for deregulated PDGFRalpha signaling in pediatric HGG. 20479398 2010
Entrez Id: 208
Gene Symbol: AKT2
AKT2 		0.260 AlteredExpression disease BEFREE AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion. 20514445 2010
Entrez Id: 3417
Gene Symbol: IDH1
IDH1 		0.400 GeneticVariation disease BEFREE IDH1 mutations are common in malignant gliomas in older children, suggesting that a subset of these lesions may be biologically similar to malignant gliomas arising in younger adults and may be associated with a more favorable prognosis. 20725730 2011
Entrez Id: 4255
Gene Symbol: MGMT
MGMT 		0.400 PosttranslationalModification disease BEFREE MGMT promoter methylation in malignant gliomas. 20725792 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.100 AlteredExpression disease BEFREE Epidermal growth factor receptor (EGFR) gene amplification and protein expression in malignant gliomas (anaplastic astrocytoma, AA and glioblastoma, GBL) were suggested to be correlated with the degree of malignancy. 21455841 2011
Entrez Id: 7980
Gene Symbol: TFPI2
TFPI2 		0.020 AlteredExpression disease BEFREE TFPI-2 expression was absent in five of nine investigated high-grade glioma cell lines. 21530612 2011
Entrez Id: 10859
Gene Symbol: LILRB1
LILRB1 		0.020 Biomarker disease BEFREE MiR-7-based gene treatment may be a novel anti-invasion therapeutic strategy for malignant glioma. 22120825 2011
Entrez Id: 9212
Gene Symbol: AURKB
AURKB 		0.020 Biomarker disease BEFREE Aurora kinase B/C inhibition impairs malignant glioma growth in vivo. 22382783 2012
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A 		0.010 AlteredExpression disease BEFREE miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis. 22479456 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.070 Biomarker disease BEFREE STAT3 alone was insufficient to induce tumor formation; however, coexpression of STAT3 with PDGFB in mice resulted in a significantly higher incidence of HGGs than PDGFB alone. 22753228 2012
Entrez Id: 2146
Gene Symbol: EZH2
EZH2 		0.020 AlteredExpression disease BEFREE EZH2 has been implicated in stem cell maintenance and is overexpressed in hematological and solid malignancie`s including malignant glioma. 23077658 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.600 GeneticVariation disease BEFREE TP53 mutation decreases the chemosensitivity of malignant gliomas to temozolomide. 23224642 2013
Entrez Id: 2059
Gene Symbol: EPS8
EPS8 		0.010 Biomarker disease BEFREE Eps8 promotes cellular growth of human malignant gliomas. 23229386 2013
Entrez Id: 115426
Gene Symbol: UHRF2
UHRF2 		0.010 AlteredExpression disease BEFREE UHRF2 mRNA expression is low in malignant glioma but silencing inhibits the growth of U251 glioma cells in vitro. 23244124 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.100 AlteredExpression disease BEFREE Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma. 23617883 2013
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.340 Biomarker disease BEFREE Cyclooxygenase-2 (COX-2) is linked to poor prognosis in patients with malignant gliomas. 23635401 2013
Entrez Id: 85415
Gene Symbol: RHPN2
RHPN2 		0.010 Biomarker disease BEFREE RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation. 23774217 2013