|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We propose that the disregulation of p73 contributes to tumorigenesis and that p53-related proteins operate in a network of developmental and cell cycle controls.
|
9288759 |
1997 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Loss of p73 has been demonstrated in neuroblastomas and its involvement in tumorigenesis has been suggested to occur in other neuroectodermal cancers.
|
9918412 |
1998 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings strongly suggest that p73 may play an important role in lung tumorigenesis through activation of a silent allele and overexpression of wild-type p73 rather than as a tumor suppressor.
|
9622072 |
1998 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These data suggest that the p73 gene is not playing an essential role, but expression of p73 may associate with tumor growth in prostatic carcinogenesis.
|
9605745 |
1998 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These results suggest that, at least in esophageal carcinomas, allelic loss or mutation of p73 may not be a main genetic event for the tumorigenesis as it is with p53.
|
9797131 |
1998 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that p73 may play a role in hepatocellular carcinogenesis in a different manner from a Knudson two-hit model.
|
10408709 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data suggest that the p73 gene is unlikely to be essential in melanoma tumorigenesis.
|
9892203 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results suggest that need for further functional analysis of the role of p73 in lung carcinogenesis.
|
10408409 |
1999 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To investigate the role of the p73 gene in human carcinogenesis, we studied genetic alterations of this gene in various human cancers.
|
10218465 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We have investigated two hypotheses: (a) p73 is mutated in diverse types of human cancer, and (b) p73 is functionally redundant with p53 in carcinogenesis so that mutations would be exclusive in these two genes.
|
10362363 |
1999 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The early suggestion that monoallelic expression of p73 contributed to carcinogenesis needs to be interpreted cautiously in light of data showing interindividual and intraindividual variation with respect to monoallelic expression of p73 and the finding that p73 mRNA levels are generally increased, rather than decreased, in a host of tumors relative to normal cells.
|
10618710 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We have investigated the hypotheses that: (a) p63 is mutated in diverse types of human cancers; and (b) p63 functions in the same pathway as p53 and p73 in the process of carcinogenesis; therefore, mutations in these three genes would be mutually exclusive.
|
10485447 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Because intragenic p73 mutations in tumors have not been reported and imprinting is idiosyncratic, tumor-specific changes in wild-type p73 expression levels become the most reliable guide toward identifying the normal function of p73 and its role in tumorigenesis.
|
10397274 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings strongly suggest that p73 is not the target of 1p36 LOH in ovarian adenocarcinomas but indicate the presence of an, as yet unidentified, tumour suppressor gene in this region that plays an important role in ovarian tumorigenesis.
|
10467409 |
1999 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our observations suggest that allelic loss, expression levels and mutations of the p73 gene may not contribute to oncogenesis of primary breast cancers.
|
10371354 |
1999 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
To explore the candidacy of p73 as a suppressor in bladder tumorigenesis, we examined expression level, allelic origin, and mutation of p73 mRNA in 45 primary bladder carcinomas.
|
10383132 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Additional studies are required to determine the role, if any, that p73 and p51 play in cell growth control and carcinogenesis.
|
10203277 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data suggest that the p73 is unlikely to be a tumor suppressor gene, but that overexpression of p73 may contribute to tumorigenesis in bladder cancer.
|
10102633 |
1999 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These results suggest that allelic loss of the p73 gene may be a later event in NBL tumorigenesis.
|
10023682 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Taken together, this study argues that p73 is not a target of genetic alteration in gastric carcinogenesis and suggests that overexpression of p73 might be triggered by physiological stresses accompanied with outgrowth of tumors, such as hypoxia or nutrient deprivation.
|
10815895 |
2000 |
|
ARHGAP24
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
In conclusion, LOH, allele silencing and decreased expression of the p73 gene may play a role in breast carcinogenesis.
|
11103943 |
2000 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These results suggest that p73 overexpression is a molecular alteration that could be implicated in the tumorigenesis of breast carcinomas and, eventually, in a poor clinical behavior.
|
11510689 |
2001 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Somatic mutations in p73 and p51 are not important in prostatic carcinogenesis.
|
11340630 |
2001 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data are consistent with the current model of p14ARF and p53 interaction as a complex network rather than a simple linear pathway and indicate a possible role for an E2F-1-mediated failsafe, p53-independent, apoptotic pathway involving p73 in human lung carcinogenesis.
|
11454718 |
2001 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Therefore further insight into the function and regulation of these structurally and functionally diverse p73 proteins is needed to elucidate the role of TP73 for apoptosis and human tumorigenesis.
|
11595834 |
2001 |