|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Based on the functional interaction between p53 and p73 in carcinogenesis, we investigated the combined effect of p73 G4C14-to-A4T14 and p53 gene polymorphisms and their interaction with selected environmental factors, on the risk for gastric cancer in a hospital-based case-control study conducted in Italy.
|
19386249 |
2009 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These results suggest that p73 overexpression is a molecular alteration that could be implicated in the tumorigenesis of breast carcinomas and, eventually, in a poor clinical behavior.
|
11510689 |
2001 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Loss of p73 has been demonstrated in neuroblastomas and its involvement in tumorigenesis has been suggested to occur in other neuroectodermal cancers.
|
9918412 |
1998 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system.
|
30530920 |
2018 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our study indicates that (1) p63 and p73 expression may represent an early event in HNSC tumorigenesis, (2) the lack of correlation between p73 or p63 and p53 expression suggests an independent and/or compensatory functional role, (3) p73 expression may play a part in HNSC progression, and (4) p73 and p63 may function as oncogenes in the development of these tumors.
|
11957139 |
2002 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that p73 may play a role in hepatocellular carcinogenesis in a different manner from a Knudson two-hit model.
|
10408709 |
1999 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Somatic mutations in p73 and p51 are not important in prostatic carcinogenesis.
|
11340630 |
2001 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Variation in p73 may alter the interaction between the E6 protein and p73 and, thus, alter the risk for HPV-associated carcinogenesis.
|
18988287 |
2008 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
p53 family proteins and VEGF play a pivotal role in colorectal carcinogenesis. p53 prognostic potential is augmented by p73 and p63 aberrations indicating a synergistic effect between the three family members.
|
23996743 |
2014 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that p73 may serve as a tumor suppressor gene and its expression plays a role in tumorigenesis in Japanese patients with breast cancer.
|
21933556 |
2011 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Taken together, this study argues that p73 is not a target of genetic alteration in gastric carcinogenesis and suggests that overexpression of p73 might be triggered by physiological stresses accompanied with outgrowth of tumors, such as hypoxia or nutrient deprivation.
|
10815895 |
2000 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, it plays a role in carcinogenesis and controls tumor sensitivity to treatment. p73 is commonly expressed in tumor cells in hematological malignancies.
|
16541141 |
2006 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings provide an explanation for the fundamentally different functions of p53 and p73 in tumorigenesis.
|
12584188 |
2003 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data suggest that the p73 gene is unlikely to be essential in melanoma tumorigenesis.
|
9892203 |
1999 |
|
ARHGAP24
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
In conclusion, LOH, allele silencing and decreased expression of the p73 gene may play a role in breast carcinogenesis.
|
11103943 |
2000 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results suggest that need for further functional analysis of the role of p73 in lung carcinogenesis.
|
10408409 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data are consistent with the current model of p14ARF and p53 interaction as a complex network rather than a simple linear pathway and indicate a possible role for an E2F-1-mediated failsafe, p53-independent, apoptotic pathway involving p73 in human lung carcinogenesis.
|
11454718 |
2001 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To investigate the role of the p73 gene in human carcinogenesis, we studied genetic alterations of this gene in various human cancers.
|
10218465 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We have investigated two hypotheses: (a) p73 is mutated in diverse types of human cancer, and (b) p73 is functionally redundant with p53 in carcinogenesis so that mutations would be exclusive in these two genes.
|
10362363 |
1999 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this minireview, we describe the contribution of the p53, p63, and p73 to human pathology with emphasis on their different roles in development and tumorigenesis.
|
18348649 |
2008 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings strongly suggest that p73 may play an important role in lung tumorigenesis through activation of a silent allele and overexpression of wild-type p73 rather than as a tumor suppressor.
|
9622072 |
1998 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The transcription factor p73 belongs to the p53-family and regulates tumorigenesis via its two N-terminal isoforms, with (TAp73) or without (ΔNp73) a transactivation domain.
|
25514460 |
2014 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These data provide evidence that the p73 gene functions as an important regulator of telomerase activity with implications for embryonic development, cellular differentiation and tumorigenesis.
|
16205639 |
2006 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The early suggestion that monoallelic expression of p73 contributed to carcinogenesis needs to be interpreted cautiously in light of data showing interindividual and intraindividual variation with respect to monoallelic expression of p73 and the finding that p73 mRNA levels are generally increased, rather than decreased, in a host of tumors relative to normal cells.
|
10618710 |
1999 |