|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Although tumors show changes in the expression level of p73 and differences in the expression pattern of p73 isoforms, mutations are not commonly observed making it difficult to infer p73's role in tumorigenesis.
|
18583938 |
2008 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The ultimate effect of p73 in oncogenesis is thought to depend on the apoptotic TA to antiapoptotic DeltaN isoforms' ratio.
|
20528922 |
2010 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, the impact of p73 on tumorigenesis depends on a subtle balance between tumor-promoting and -suppressing isoforms.
|
24742294 |
2014 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These data suggest that the p73 gene is not playing an essential role, but expression of p73 may associate with tumor growth in prostatic carcinogenesis.
|
9605745 |
1998 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We have investigated the hypotheses that: (a) p63 is mutated in diverse types of human cancers; and (b) p63 functions in the same pathway as p53 and p73 in the process of carcinogenesis; therefore, mutations in these three genes would be mutually exclusive.
|
10485447 |
1999 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
However, its N-terminal truncated isoforms have been associated with oncogenesis due to their capacity to act as dominant negatives of p53 and the transactivation (TA) isoforms of p73.
|
26182360 |
2015 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This is in agreement with the possible role of p73 in cervical carcinogenesis, namely, in human papillomavirus-infected transition zone subjected to the action of estrogens and in conjunction with disruption of differentiation program of this squamous epithelium that occurs in HSIL phase before the next step to invasiveness and squamous cervical cancer.
|
21711160 |
2012 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To determine how p63 and p73 are involved in tumorigenesis and normal development, we used cDNA microarray to examine 9216 genes in human colorectal cancer cells.
|
15856012 |
2005 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Because intragenic p73 mutations in tumors have not been reported and imprinting is idiosyncratic, tumor-specific changes in wild-type p73 expression levels become the most reliable guide toward identifying the normal function of p73 and its role in tumorigenesis.
|
10397274 |
1999 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our recent study revealed miR-1246 as a novel target of p53 and its analogs p63 and p73 to suppress the expression of DYRK1A and consequently activate NFAT, both of which are associated with Down syndrome and possibly with tumorigenesis.
|
22751441 |
2012 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We generated an mTOR-p73 signature that is enriched for p73 target genes and miRNAs that are involved in mesenchymal differentiation and tumorigenesis, can classify rhabdomyosarcomas by clinical subtype, and can predict patient outcome.
|
21245298 |
2011 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings strongly suggest that p73 is not the target of 1p36 LOH in ovarian adenocarcinomas but indicate the presence of an, as yet unidentified, tumour suppressor gene in this region that plays an important role in ovarian tumorigenesis.
|
10467409 |
1999 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our observations suggest that allelic loss, expression levels and mutations of the p73 gene may not contribute to oncogenesis of primary breast cancers.
|
10371354 |
1999 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Mutations in p73 are rare in cancer.Emerging evidence suggests that the relative expression of various p73 isoforms may contribute to tumorigenesis.
|
16980297 |
2006 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our data also indicate that interactions between p63 and p73 play an important role in tumorigenesis of EBD carcinoma.
|
17385050 |
2007 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Therefore further insight into the function and regulation of these structurally and functionally diverse p73 proteins is needed to elucidate the role of TP73 for apoptosis and human tumorigenesis.
|
11595834 |
2001 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
To explore the candidacy of p73 as a suppressor in bladder tumorigenesis, we examined expression level, allelic origin, and mutation of p73 mRNA in 45 primary bladder carcinomas.
|
10383132 |
1999 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These results suggest that, at least in esophageal carcinomas, allelic loss or mutation of p73 may not be a main genetic event for the tumorigenesis as it is with p53.
|
9797131 |
1998 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, a candidate gene for parathyroid tumorigenesis is present within a 7-cM region at 1p36.3, however p73 is unlikely to be the target of the LOH at 1p36.3.
|
11301342 |
2001 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Additional studies are required to determine the role, if any, that p73 and p51 play in cell growth control and carcinogenesis.
|
10203277 |
1999 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our results demonstrate a novel mechanism for activation of beta-catenin in gastrointestinal tumors and support the concept that overexpression of p73 isoforms can play an important role in tumorigenesis.
|
15374945 |
2004 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results indicate the involvement of p73 protein in MB tumorigenesis and define TP73 as a potential prognostic and therapeutic target for medulloblastoma.
|
17912537 |
2007 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Both p63 and p73 exhibit tissue-specific roles in normal development and a complex contribution to tumorigenesis that is due to their expression as multiple protein isoforms.
|
17334395 |
2007 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although the tumor suppressor function of p53 is clearly defined, the role of p73 in tumorigenesis is still a matter of debate.
|
20676143 |
2010 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We propose that the disregulation of p73 contributes to tumorigenesis and that p53-related proteins operate in a network of developmental and cell cycle controls.
|
9288759 |
1997 |