Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1392
Gene Symbol: CRH
CRH 		0.300 Biomarker disease CTD_human A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats. 11797056 2001
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. 11923462 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. 11751029 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. 11923462 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. 11751029 2002
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3 		0.600 Therapeutic disease CTD_human Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. 11746736 2002
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3 		0.600 Biomarker disease CTD_human Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. 11746736 2002
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4 		0.550 Biomarker disease PSYGENET Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American individuals. 12218660 2002
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4 		0.550 GeneticVariation disease BEFREE Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American individuals. 12218660 2002
Entrez Id: 5173
Gene Symbol: PDYN
PDYN 		0.540 Biomarker disease PSYGENET Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse. 11992566 2002
Entrez Id: 5173
Gene Symbol: PDYN
PDYN 		0.540 GeneticVariation disease BEFREE Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse. 11992566 2002
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker disease CTD_human Temporal concordance of cocaine effects on mood states and neuroendocrine hormones. 11750770 2002
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A 		0.300 Biomarker disease CTD_human 5-HT1A agonist/antagonist modification of cocaine stimulant effects: implications for cocaine mechanisms. 11853856 2002
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1 		0.550 Biomarker disease CTD_human Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. 12815747 2003
Entrez Id: 1814
Gene Symbol: DRD3
DRD3 		0.520 Biomarker disease PSYGENET BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. 12847556 2003
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1 		0.330 Biomarker disease CTD_human This suggests that targeting GR function in the brain could provide new therapeutic strategies to treat cocaine addiction for which there is no available treatment. 12805318 2003
Entrez Id: 10280
Gene Symbol: SIGMAR1
SIGMAR1 		0.310 Biomarker disease CTD_human Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward. 12736327 2003
Entrez Id: 2354
Gene Symbol: FOSB
FOSB 		0.300 Therapeutic disease CTD_human Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. 12657709 2003
Entrez Id: 1133
Gene Symbol: CHRM5
CHRM5 		0.300 Biomarker disease CTD_human Role for M5 muscarinic acetylcholine receptors in cocaine addiction. 13130510 2003
Entrez Id: 1066
Gene Symbol: CES1
CES1 		0.300 Therapeutic disease CTD_human Human carboxylesterase 1: from drug metabolism to drug discovery. 12773168 2003
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1 		0.300 Biomarker disease CTD_human Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. 14684464 2003
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1 		0.300 Therapeutic disease CTD_human Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. 14684464 2003
Entrez Id: 2668
Gene Symbol: GDNF
GDNF 		0.300 Therapeutic disease CTD_human Transplantation of glial cell line-derived neurotrophic factor-expressing cells into the striatum and nucleus accumbens attenuates acquisition of cocaine self-administration in rats. 14622243 2003
Entrez Id: 1066
Gene Symbol: CES1
CES1 		0.300 Therapeutic disease CTD_human Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. 12679808 2003
Entrez Id: 2354
Gene Symbol: FOSB
FOSB 		0.300 Biomarker disease CTD_human Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. 12657709 2003