Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.500 Biomarker phenotype RGD Although the roles of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF) in pathologic neovascularization have been well characterized in certain tissues, their particular functions and expression patterns in choroidal neovascularization (CNV) have not been clearly established. 19013152 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.500 Biomarker phenotype CTD_human Rapid regression of disc neovascularization in a patient with proliferative diabetic retinopathy following adjunctive intravitreal bevacizumab. 16680105 2006
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.200 Therapeutic phenotype RGD Melissa officinalis extract inhibits laser-induced choroidal neovascularization in a rat model. 25314292 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.200 Therapeutic phenotype RGD Melissa officinalis extract inhibits laser-induced choroidal neovascularization in a rat model. 25314292 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.200 Biomarker phenotype RGD Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat. 25380250 2014
Entrez Id: 2321
Gene Symbol: FLT1
FLT1
0.200 Therapeutic phenotype RGD Long-term efficacy of ciliary muscle gene transfer of three sFlt-1 variants in a rat model of laser-induced choroidal neovascularization. 23804076 2013
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.200 Therapeutic phenotype RGD Inhibitory role of adiponectin peptide I on rat choroidal neovascularization. 22633972 2012
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.200 Biomarker phenotype RGD Effect of sorafenib on experimental choroidal neovascularization in the rat. 20497436 2010
Entrez Id: 3082
Gene Symbol: HGF
HGF
0.200 Biomarker phenotype RGD Although the roles of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF) in pathologic neovascularization have been well characterized in certain tissues, their particular functions and expression patterns in choroidal neovascularization (CNV) have not been clearly established. 19013152 2009
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.200 Biomarker phenotype RGD This work provides evidence for an important role of VAP-1 in the recruitment of macrophages to CNV lesions, establishing a novel link between VAP-1 and angiogenesis. 18436961 2008
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.200 Biomarker phenotype RGD Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization. 16689928 2006
Entrez Id: 3791
Gene Symbol: KDR
KDR
0.200 Therapeutic phenotype RGD Selective photodynamic therapy by targeted verteporfin delivery to experimental choroidal neovascularization mediated by a homing peptide to vascular endothelial growth factor receptor-2. 15249365 2004
Entrez Id: 5176
Gene Symbol: SERPINF1
SERPINF1
0.200 Biomarker phenotype RGD CNV is inversely correlated with PEDF.The down-regulation of PEDF may be one of the main reasons for the formation and development of CNV. 15312607 2004
Entrez Id: 3685
Gene Symbol: ITGAV
ITGAV
0.200 Biomarker phenotype RGD Integrin alpha(v)beta3 is predominantly expressed on endothelial cells in choroidal neovascularization (CNV). 15287373 2004
Entrez Id: 3791
Gene Symbol: KDR
KDR
0.200 Therapeutic phenotype RGD Suppression of experimental choroidal neovascularization utilizing KDR selective receptor tyrosine kinase inhibitor. 12937991 2003
Entrez Id: 1890
Gene Symbol: TYMP
TYMP
0.200 Biomarker phenotype RGD To investigate the possible role of TP and doxifluridine in choroidal neovascularization (CNV), the expression level of TP was measured and the effect of doxifluridine was investigated in rat eyes with experimental CNV. 12556409 2003
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
0.200 Therapeutic phenotype RGD The expression of bFGF associated with CNV formation was also significantly reduced by the TNP treatment. 10359334 1999
Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
0.100 Biomarker phenotype HPO
Entrez Id: 7299
Gene Symbol: TYR
TYR
0.100 GeneticVariation phenotype CLINVAR
Entrez Id: 64132
Gene Symbol: XYLT2
XYLT2
0.100 Biomarker phenotype HPO
Entrez Id: 7299
Gene Symbol: TYR
TYR
0.100 CausalMutation phenotype CLINVAR
Entrez Id: 189
Gene Symbol: AGXT
AGXT
0.100 Biomarker phenotype HPO
Entrez Id: 3426
Gene Symbol: CFI
CFI
0.100 Biomarker phenotype HPO
Entrez Id: 10516
Gene Symbol: FBLN5
FBLN5
0.100 Biomarker phenotype HPO
Entrez Id: 64131
Gene Symbol: XYLT1
XYLT1
0.100 Biomarker phenotype HPO