×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.120
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.120
Biomarker
disease
BEFREE
We utilized a genetic brainstem glioma mouse model driven by platelet-derived growth factor-B and p53 loss using abcg2/abcb1 wild-type (ABC WT) or abcg2/abcb1 knockout mice (ABC KO).
26883271
2016
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.120
AlteredExpression
disease
BEFREE
Immunofluorescence of p53 was shown activated following BGSC s differentiation.
29937714
2018
×
Entrez Id:
90
Gene Symbol:
ACVR1
ACVR1
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
2260
Gene Symbol:
FGFR1
FGFR1
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
3020
Gene Symbol:
H3-3A
H3-3A
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
3418
Gene Symbol:
IDH2
IDH2
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
3417
Gene Symbol:
IDH1
IDH1
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
8354
Gene Symbol:
H3C11
H3C11
0.100
GeneticVariation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
5077
Gene Symbol:
PAX3
PAX3
0.030
AlteredExpression
disease
BEFREE
The results indicate that Pax3 regulates GFAP expression, and that Pax3 may contribute to the evolution of BGSC s towards malignancy.
27432276
2016
×
Entrez Id:
5077
Gene Symbol:
PAX3
PAX3
0.030
AlteredExpression
disease
BEFREE
Collectively, these data suggest that regional Pax3 expression not only marks a novel subset of BSG but also contributes to PDGF-B-induced brainstem gliomagenesis.
25330836
2014
×
Entrez Id:
5077
Gene Symbol:
PAX3
PAX3
0.030
Biomarker
disease
BEFREE
Then, the function of PAX3 in BGSC s were sequentially investigated <i>in vitro</i> and <i>in vivo</i>.
29937714
2018
×
Entrez Id:
10058
Gene Symbol:
ABCB6
ABCB6
0.010
Biomarker
disease
BEFREE
Elacridar, an ABCG2 and ABCB1 inhibitor, significantly increases the efficacy of dasatinib in brainstem glioma -bearing ABC WT mice (42 vs. 59 days).
26883271
2016
×
Entrez Id:
406900
Gene Symbol:
MIR106B
MIR106B
0.010
Biomarker
disease
BEFREE
In conclusion, our studies provide evidence that miR-20a and miR-106b may serve as putative causative involvement of malignant progression of pediatric BSG , thereby serving as likely novel targets for constraining the rapid fatal course of pediatric BSG.
22825541
2012
×
Entrez Id:
9429
Gene Symbol:
ABCG2
ABCG2
0.010
Biomarker
disease
BEFREE
Elacridar, an ABCG2 and ABCB1 inhibitor, significantly increases the efficacy of dasatinib in brainstem glioma -bearing ABC WT mice (42 vs. 59 days).
26883271
2016
×
Entrez Id:
10215
Gene Symbol:
OLIG2
OLIG2
0.010
Biomarker
disease
BEFREE
Here we report that Olig2 expression and DIPG differentiation are mutually exclusive events in vitro, and only DIPG cells that retained Olig2 in vitro formed robust Olig2 -positive brainstem glioma with 100% penetrance in a xenograft model.
28339768
2017
×
Entrez Id:
8932
Gene Symbol:
MBD2
MBD2
0.010
GeneticVariation
disease
BEFREE
Our results demonstrate that increasing H3K27 methylation by inhibiting K27 demethylase is a valid therapeutic strategy for treating K27M -expressing brainstem glioma .
25401693
2014
×
Entrez Id:
56994
Gene Symbol:
CHPT1
CHPT1
0.010
Biomarker
disease
BEFREE
Brainstem glioma -bearing rats treated with hAT-MSC.rCE and CPT -11 survived 5d more than rats treated with CPT -11 only (p=0.0018).
21664124
2012
×
Entrez Id:
79947
Gene Symbol:
DHDDS
DHDDS
0.010
Biomarker
disease
BEFREE
Brainstem glioma -bearing rats treated with hAT-MSC.rCE and CPT -11 survived 5d more than rats treated with CPT -11 only (p=0.0018).
21664124
2012
×
Entrez Id:
80381
Gene Symbol:
CD276
CD276
0.010
Biomarker
disease
BEFREE
In the non-diffuse brainstem glioma group, none of the eight WHO grade I specimens showed B7-H3 immunoreactivity and nine of the 24 WHO grade II specimens (37.5 %) showed B7-H3 immunoreactivity.
23232807
2013
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
0.010
Biomarker
disease
BEFREE
In addition, hypoxia inducible factor-1α (HIF-1α ) might be a potential upstream regulator of PAX3 in differentiated BGSC s under hypoxia.
29937714
2018
×
Entrez Id:
596
Gene Symbol:
BCL2
BCL2
0.010
Biomarker
disease
BEFREE
New therapies targeting Bcl-2 must induce apoptosis in BGSC s, thus, resulting in treatment or even eradication of glioma.
22562364
2012