Gene: APOE ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 GeneticVariation disease BEFREE Conversely, patients negative for the APOE ɛ4 allele and with early-onset AD are more likely to be predisposed to vulnerability of cerebral networks beyond the medial temporal lobes. 21185234 2011
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients. 27023435 2017
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease BEFREE Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia. 8075646 1994
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease BEFREE apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. 11129341 2000
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses. 29107063 2018
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development. 30319691 2018
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers. 30320580 2018
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Elevated serum pesticide levels and risk for Alzheimer disease. 24473795 2014
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease BEFREE Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset. 19335933 2009
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. 8346443 1993
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. 19734902 2009
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men. 20819998 2010
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. 23571587 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. 23296339 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. 10799751 2000
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. 19605830 2009
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. 23060451 2012
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians. 27260402 2016
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis. 22381401 2012
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 SusceptibilityMutation disease CLINVAR Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. 9343467 1997