×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
We analyzed the 13 SNPs in the SORL1 gene that had been studied in previous reports using case-control methods and included sex, apolipoprotein E (APOE ) genotype, and age at AD onset as covariates.
19822782
2009
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Pathogenic variants in the autosomal dominant genes PSEN1, PSEN2, or APP, APOE4 alleles, and rare variants within TREM2, SORL1, and ABCA7 contribute to early-onset Alzheimer's disease (EOAD).
31381512
2019
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease .
9875528
1998
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
GeneticVariation
disease
BEFREE
Conversely, patients negative for the APOE ɛ4 allele and with early-onset AD are more likely to be predisposed to vulnerability of cerebral networks beyond the medial temporal lobes.
21185234
2011
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
23571587
2013
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
23296339
2013
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease.
10799751
2000
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.
19605830
2009
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.
23060451
2012
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.
27260402
2016
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: a meta-analysis.
22381401
2012
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
SusceptibilityMutation
disease
CLINVAR
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
9343467
1997
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients.
27023435
2017
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.
29107063
2018
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development.
30319691
2018
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
30320580
2018
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Elevated serum pesticide levels and risk for Alzheimer disease.
24473795
2014
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
8346443
1993
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
24162737
2013
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
19734902
2009
×
Entrez Id:
348
Gene Symbol:
APOE
APOE
0.500
Biomarker
disease
CTD_human
Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men.
20819998
2010