Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.010 Biomarker disease BEFREE <b>Results:</b> Our findings indicated that the variations in the IL-6 and CRP concentrations in patients with digestive system cancer did not differ between the supplementation groups and the controls. 31573353 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.010 GeneticVariation disease BEFREE HIF-1α P582S and A588T polymorphisms and digestive system cancer risk-a meta-analysis. 24293391 2014
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.010 GeneticVariation disease BEFREE VEGF +405G/C (rs2010963) polymorphisms and digestive system cancer risk: a meta-analysis. 24474253 2014
Entrez Id: 84868
Gene Symbol: HAVCR2
HAVCR2
0.010 GeneticVariation disease BEFREE TIM-3 -574G/T polymorphism was associated with an increased risk of digestive system cancer and other cancer in Chinese Han population. 27008699 2016
Entrez Id: 27250
Gene Symbol: PDCD4
PDCD4
0.010 AlteredExpression disease BEFREE PDCD4 expression was significantly associated with the differentiation status of head and neck cancer (OR 4.25, 95% CI 1.87-9.66) and digestive system cancer (OR 2.87, 95% CI 1.84-4.48). 27852288 2016
Entrez Id: 407009
Gene Symbol: MIR224
MIR224
0.010 AlteredExpression disease BEFREE MiR-224-5p is up-regulated in digestive system cancers (SMD=0.69, 95% CI: 0.43-0.96, P<0.0001) and exhibits a moderate diagnostic ability (AUC=0.84, 95% CI: 0.80-0.87). 29169158 2017
Entrez Id: 22974
Gene Symbol: TPX2
TPX2
0.010 AlteredExpression disease BEFREE TPX2 expression might be associated with TNM stage and pathological grade in digestive system cancer. 29551902 2018
Entrez Id: 50507
Gene Symbol: NOX4
NOX4
0.010 Biomarker disease BEFREE NOX4, a new genetic target for anti-cancer therapy in digestive system cancer. 30058122 2018
Entrez Id: 4751
Gene Symbol: NEK2
NEK2
0.010 Biomarker disease BEFREE NEK2 might act as a useful prognostic predictor and a potential therapeutic target in DSCs. 30425509 2018
Entrez Id: 140828
Gene Symbol: LINC00261
LINC00261
0.010 Biomarker disease BEFREE LINC00261 plays a vital role in tumorigenesis and metastasis of digestive system cancer. 31812439 2020
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR
0.030 Biomarker disease BEFREE A quantitative meta-analysis was conducted with standard statistical methods for eligible papers on the prognostic value of HOTAIR in digestive system cancers. 25754087 2015
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.010 GeneticVariation disease BEFREE A total of 77 patients with various types of digestive system cancers were screened for CYP2A6 genetic polymorphisms. 22322240 2012
Entrez Id: 10397
Gene Symbol: NDRG1
NDRG1
0.010 AlteredExpression disease BEFREE Accordingly, we herein conducted a meta-analysis to explore whether NDRG1 expression is correlated with overall survival (OS) and clinicopathological characteristics of patients with digestive system cancers. 30313035 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.010 Biomarker disease BEFREE Apart from the commonly mutated founder genes, e.g., KRAS and TP53, we now have detailed information on additional and less frequent genomic events for every major digestive system cancer. 28178700 2017
Entrez Id: 1803
Gene Symbol: DPP4
DPP4
0.010 GeneticVariation disease BEFREE Association of dipeptidyl peptidase 4 inhibitors with risk of metastases in patients with type 2 diabetes and breast, prostate or digestive system cancer. 28169131 2017
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.010 Biomarker disease BEFREE Clinical value of octamer-binding transcription factor 4 as a prognostic marker in patients with digestive system cancers: A systematic review and meta-analysis. 28320060 2017
Entrez Id: 5820
Gene Symbol: PVT1
PVT1
0.020 AlteredExpression disease BEFREE Elevated PVT1 expression were significantly related to poor overall survival (OS) [HR = 1.86, 95% CI (1.44, 2.28); p<0.0001] in digestive system cancers. 28968599 2017
Entrez Id: 2693
Gene Symbol: GHSR
GHSR
0.300 Biomarker disease CTD_human For the first time, we identified the distribution of ghrelin receptor in digestive system cancers. 18064392 2007
Entrez Id: 4162
Gene Symbol: MCAM
MCAM
0.010 AlteredExpression disease BEFREE Furthermore, the subgroup analysis revealed that the associations between CD146 overexpression and the outcome endpoints (OS or TTP) were significant in Mongoloid patients and Caucasian patients, as well in patients with lung cancer and digestive system cancer. 28652617 2017
Entrez Id: 1399
Gene Symbol: CRKL
CRKL
0.010 Biomarker disease BEFREE Here, we showed that CRKL is involved in colon cancer, which is the most common form of cancer of the digestive system. 24389200 2014
Entrez Id: 4017
Gene Symbol: LOXL2
LOXL2
0.010 Biomarker disease BEFREE High LOXL2 protein expression is significantly associated with worse clinical outcomes in DSCs and its expression level may represent a candidate prognostic biomarker in these cancers. 30997684 2019
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.010 GeneticVariation disease BEFREE However, no significant association with risk of digestive system cancers was observed for TLR2 -196 to -174 del and TLR4 rs4986791. 24376595 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.010 GeneticVariation disease BEFREE However, no significant association with risk of digestive system cancers was observed for TLR2 -196 to -174 del and TLR4 rs4986791. 24376595 2013
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.010 GeneticVariation disease BEFREE Hypoxia-inducible factor-1 (HIF-1) influences cancer progression and metastasis through various mechanisms, and HIF-1α polymorphisms are reportedly associated with many cancers; however, the associations of HIF-1α P582S and A588T polymorphisms with the risk of digestive system cancer remain inconclusive. 24293391 2014
Entrez Id: 406913
Gene Symbol: MIR126
MIR126
0.010 Biomarker disease BEFREE In addition, the current review has discussed the potential clinical application of miR-126 as a biomarker and therapeutic target for DSCs. 30655735 2019