Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker phenotype BEFREE Ribosylation-derived AGEs downregulated the BDNF-TrkB pathway in rat brains and N2a cells, leading to GSK-3β activation-mediated tau hyperphosphorylation, which was involved in the observed rat memory loss. 31381511 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker phenotype BEFREE The administration of ANA-12, a TrkB inhibitor, reversed the behavioral and molecular effects of stem cell transplantation suggesting involvement of BDNF-TrkB pathway in the rescue of memory loss. 31250384 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker phenotype BEFREE Thus, the proposed link between BDNF, exercise and cognition may have critical therapeutic implications for the prevention and amelioration of memory loss and cognitive impairment in Alzheimer's disease and associated dementias. 30326283 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker phenotype BEFREE Brain-derived neurotrophic factor (BDNF) gene delivery to the entorhinal cortex is a candidate for treatment of Alzheimer's disease (AD) to reduce neurodegeneration that is associated with memory loss. 29535375 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker phenotype BEFREE It has been suggested that memory loss also involves a decrease in neurotrophic factors, including brain-derived neurotrophic factor (BDNF). 30618722 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression phenotype BEFREE Overall, our results indicate that the Shh pathway can induce the expression of BDNF/NT3, and DA causes memory loss by inactivation of Shh pathway signaling to BDNF/NT3 in MHE rats, which is reversed by Nrg. 28840059 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation phenotype BEFREE While allelic variation in BDNF Val66Met may influence Aβ+ related neurodegeneration and memory loss over the short term, this is not related to serum mBDNF. 28720165 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker phenotype BEFREE Decreased brain-derived neurotrophic factor (BDNF) contributes to memory loss in Alzheimer's disease (AD), and soluble assemblies of amyloid-beta (Aβ) and tau contribute to neurodegeneration. 26410307 2015
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker phenotype BEFREE These results suggest that TrkB expression of hMSCs elevates the neuronal regeneration and efficiency of BDNF delivery for treating degenerative neurological diseases accompanying memory loss. 23313493 2013
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation phenotype BEFREE Variations in two single-nucleotide polymorphisms (SNPs) within the BDNF gene have previously been associated with AD, and one of these SNPs has also been associated with memory loss and affective disorders. 15635706 2005