Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2875
Gene Symbol: GPT
GPT 		0.300 Biomarker disease CTD_human Nephrotoxic and hepatotoxic effects of triclosan and chlorhexidine in rats. 145039 1977
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2 		0.300 Biomarker disease CTD_human A phase I study of recombinant human interferon-alpha 2a or human lymphoblastoid interferon-alpha n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma. 1670585 1991
Entrez Id: 3552
Gene Symbol: IL1A
IL1A 		0.300 Therapeutic disease CTD_human The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity. 8218930 1993
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385 1995
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Therapeutic disease CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385 1995
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.300 Therapeutic disease CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385 1995
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492 1998
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Therapeutic disease CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492 1998
Entrez Id: 3589
Gene Symbol: IL11
IL11 		0.300 Therapeutic disease CTD_human Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity. 11421492 2001
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10 		0.300 Therapeutic disease CTD_human IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes. 11739529 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.300 Therapeutic disease CTD_human A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. 11743745 2001
Entrez Id: 10
Gene Symbol: NAT2
NAT2 		0.330 Biomarker disease CTD_human To determine whether acetylator status is a risk factor for antituberculosis drug-induced hepatitis, we genotyped NAT2 in 224 incident tuberculosis patients who received antituberculosis treatment. 11915035 2002
Entrez Id: 10
Gene Symbol: NAT2
NAT2 		0.330 Biomarker disease BEFREE In conclusion, slow-acetylator status of NAT2 is a significant susceptibility risk factor for antituberculosis drug-induced hepatitis. 11915035 2002
Entrez Id: 6649
Gene Symbol: SOD3
SOD3 		0.300 Therapeutic disease CTD_human EC-SOD gene therapy reduces paracetamol-induced liver damage in mice. 11529661 2002
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.300 Biomarker disease CTD_human A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury. 12153990 2002
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1 		0.340 Biomarker disease CTD_human The aim of this study was to evaluate whether the polymorphism of the CYP2E1 gene is associated with antituberculosis drug-induced hepatitis. 12668988 2003
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1 		0.340 GeneticVariation disease BEFREE The aim of this study was to evaluate whether the polymorphism of the CYP2E1 gene is associated with antituberculosis drug-induced hepatitis. 12668988 2003
Entrez Id: 6652
Gene Symbol: SORD
SORD 		0.300 Biomarker disease CTD_human Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity. 12763371 2003
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4 		0.300 Biomarker disease CTD_human [Functional analysis of drug metabolizing enzymes using gene knockout animals]. 12875239 2003
Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19 		0.300 Biomarker disease CTD_human Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene. 12963435 2003
Entrez Id: 4254
Gene Symbol: KITLG
KITLG 		0.200 Therapeutic disease CTD_mouse Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury. 12594235 2003
Entrez Id: 9360
Gene Symbol: PPIG
PPIG 		0.010 GeneticVariation disease BEFREE In conclusion, CYP 2E1 genetic polymorphism may be associated with susceptibility to antituberculosis drug-induced hepatitis. 12668988 2003
Entrez Id: 50616
Gene Symbol: IL22
IL22 		0.300 Therapeutic disease CTD_human Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. 15122762 2004
Entrez Id: 686
Gene Symbol: BTD
BTD 		0.300 Biomarker disease CTD_human Increased plasma biotinidase activity in rats with paracetamol-induced acute liver injury. 15469856 2004
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9 		0.300 Biomarker disease CTD_human Leflunomide-induced acute hepatitis. 14971821 2004