Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 GeneticVariation disease BEFREE TNF-α genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis. 22151084 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Therapeutic disease CTD_human Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. 21984482 2012
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.310 Therapeutic disease CTD_human Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. 22627062 2012
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.310 Therapeutic disease CTD_human Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. 22491424 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Therapeutic disease CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750 2011
Entrez Id: 1555
Gene Symbol: CYP2B6
CYP2B6 		0.310 Biomarker disease BEFREE Most prior genetic studies on antituberculus drug-induced hepatitis have focused on a few drug-metabolizing enzymes such as cytochrome P450 and N-acetyltransferase 2. 20485159 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Therapeutic disease CTD_human Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. 19638433 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. 19638433 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Therapeutic disease CTD_human Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. 17709330 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. 17709330 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492 1998
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Therapeutic disease CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492 1998
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385 1995
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Therapeutic disease CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385 1995
Entrez Id: 7100
Gene Symbol: TLR5
TLR5 		0.300 Biomarker disease CTD_human TLR5 silencing reduced hyperammonaemia-induced liver injury by inhibiting oxidative stress and inflammation responses via inactivating NF-κB and MAPK signals. 30508503 2019
Entrez Id: 5580
Gene Symbol: PRKCD
PRKCD 		0.300 Therapeutic disease CTD_human Protein kinase Cδ knockout mice are protected from cocaine-induced hepatotoxicity. 30393195 2019
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1 		0.300 Therapeutic disease CTD_human Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes. 30394310 2019
Entrez Id: 624
Gene Symbol: BDKRB2
BDKRB2 		0.300 Biomarker disease CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357 2019
Entrez Id: 3827
Gene Symbol: KNG1
KNG1 		0.300 Biomarker disease CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357 2019
Entrez Id: 406884
Gene Symbol: MIRLET7B
MIRLET7B 		0.300 Biomarker disease CTD_human Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats. 30125006 2018
Entrez Id: 3727
Gene Symbol: JUND
JUND 		0.300 Biomarker disease CTD_human Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury. 30515189 2018
Entrez Id: 1576
Gene Symbol: CYP3A4
CYP3A4 		0.300 Biomarker disease CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043 2018
Entrez Id: 59343
Gene Symbol: SENP2
SENP2 		0.300 Therapeutic disease CTD_human SENP2 alleviates CCl4-induced liver fibrosis by promoting activated hepatic stellate cell apoptosis and reversion. 29535048 2018
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1 		0.300 Biomarker disease CTD_human Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury. 30515189 2018