Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54361
Gene Symbol: WNT4
WNT4
0.010 AlteredExpression disease BEFREE State anxiety assessed two months before the examination was positively and negatively correlated with miR-16 and its target WNT4 mRNA levels, respectively. 24130753 2013
Entrez Id: 7349
Gene Symbol: UCN
UCN
0.300 Biomarker disease CTD_human Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons. 16488545 2006
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.010 Biomarker disease BEFREE Significant (P < 0.05) moderate negative associations existed between changes in AEA and mood states for MOD at 10 min (depression, confusion, fatigue, total mood disturbance [TMD] and state anxiety) and 30 min postexercise (confusion, TMD and state anxiety). 30973483 2019
Entrez Id: 6302
Gene Symbol: TSPAN31
TSPAN31
0.010 Biomarker disease BEFREE Significant positive relationships were obtained between SAS-2 subscales and somatic and cognitive state anxiety. 28558530 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.310 Biomarker disease CTD_human Chronic social stress and susceptibility to concentrated ambient fine particles in rats. 20194079 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.310 Biomarker disease BEFREE Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear factor kappa beta 2 (NFKB2)) were associated with trait anxiety, and variations in two genes (i.e., IL1R2, tumor necrosis factor alpha (TNFA)) were associated with state anxiety. 25249351 2015
Entrez Id: 7038
Gene Symbol: TG
TG
0.300 Biomarker disease CTD_human Hashimoto's thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice. 30373627 2018
Entrez Id: 338811
Gene Symbol: TAFA2
TAFA2
0.300 Biomarker disease CTD_human Targeted knockout of a chemokine-like gene increases anxiety and fear responses. 29339520 2018
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.010 Biomarker disease BEFREE Analysis of covariance was used to test comparative improved pain intensity on the NRS, psychologic distress on the Emotion Thermometers, and state anxiety on the State Anxiety Subscale of the State Trait Anxiety Index after controlling for respective baseline scores. 29480886 2018
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.310 GeneticVariation disease BEFREE We, thus, assessed childhood trauma (Childhood Trauma Questionnaire, CTQ) and GSE in 678 adults genotyped for 5-HTTLPR/rs25531 and their interaction on agoraphobic cognitions (Agoraphobic Cognitions Questionnaire, ACQ), social anxiety (Liebowitz Social Anxiety Scale, LSAS), and trait anxiety (State-Trait Anxiety Inventory, STAI-T). 27145764 2016
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.310 Biomarker disease CTD_human The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. 18686203 2008
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.300 Biomarker disease CTD_human Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder. 19120712 2008
Entrez Id: 50944
Gene Symbol: SHANK1
SHANK1
0.300 Biomarker disease CTD_human Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. 18272690 2008
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1
0.300 Biomarker disease CTD_human Art, alpha-1-antitrypsin polymorphisms and intense creative energy: blessing or curse? 17659342 2007
Entrez Id: 10743
Gene Symbol: RAI1
RAI1
0.300 Biomarker disease CTD_human How much is too much? Phenotypic consequences of Rai1 overexpression in mice. 18285828 2008
Entrez Id: 5697
Gene Symbol: PYY
PYY
0.010 Biomarker disease BEFREE Appetite Perceptions, Gastrointestinal Symptoms, Ghrelin, Peptide YY and State Anxiety Are Disturbed in Adolescent Females with Anorexia Nervosa and Only Partially Restored with Short-Term Refeeding. 30597915 2018
Entrez Id: 5066
Gene Symbol: PAM
PAM
0.310 Biomarker disease CTD_human Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. 19815072 2010
Entrez Id: 5066
Gene Symbol: PAM
PAM
0.310 GeneticVariation disease BEFREE We assessed person-reported outcome measures (PROMs) at baseline (hospital admission), discharge, and day 100: usefulness of BMT Roadmap (Perceived Usefulness); activation (Patient Activation Measure-Caregiver version [PAM-C]); mental health ([POMS-2®]: depression, distress, vigor, and fatigue); anxiety (State-Trait Anxiety Inventory); and quality of life (Caregiver Quality of Life Index-Cancer [CQOLC]). 30232587 2019
Entrez Id: 5020
Gene Symbol: OXT
OXT
0.300 Therapeutic disease CTD_human Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. 19228979 2009
Entrez Id: 4886
Gene Symbol: NPY1R
NPY1R
0.300 Therapeutic disease CTD_human Neuropeptide Y Y1 receptor-mediated anxiolysis in the dorsocaudal lateral septum: functional antagonism of corticotropin-releasing hormone-induced anxiety. 11440811 2001
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.300 Therapeutic disease CTD_human Neuropeptide Y Y1 receptor-mediated anxiolysis in the dorsocaudal lateral septum: functional antagonism of corticotropin-releasing hormone-induced anxiety. 11440811 2001
Entrez Id: 594857
Gene Symbol: NPS
NPS
0.300 Therapeutic disease CTD_human Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68). 21466221 2011
Entrez Id: 594857
Gene Symbol: NPS
NPS
0.300 Therapeutic disease CTD_human Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. 19339610 2009
Entrez Id: 594857
Gene Symbol: NPS
NPS
0.300 Biomarker disease CTD_human Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68). 21466221 2011
Entrez Id: 594857
Gene Symbol: NPS
NPS
0.300 Biomarker disease CTD_human Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. 19339610 2009