Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 135
Gene Symbol: ADORA2A
ADORA2A
0.300 Biomarker disease CTD_human Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. 12825092 2003
Entrez Id: 135
Gene Symbol: ADORA2A
ADORA2A
0.300 Biomarker disease CTD_human Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants. 16118787 2005
Entrez Id: 135
Gene Symbol: ADORA2A
ADORA2A
0.300 Biomarker disease CTD_human Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. 18305461 2008
Entrez Id: 135
Gene Symbol: ADORA2A
ADORA2A
0.300 Biomarker disease CTD_human Genetics of caffeine consumption and responses to caffeine. 20532872 2010
Entrez Id: 276
Gene Symbol: AMY1A
AMY1A
0.020 Biomarker disease BEFREE Immediately before and after a mindfulness session, participants completed questionnaires to assess the short-term effects on mood and state anxiety and provided saliva samples to assess salivary alpha amylase (sAA) concentrations. 30395806 2019
Entrez Id: 276
Gene Symbol: AMY1A
AMY1A
0.020 Biomarker disease BEFREE No mediating roles of salivary alpha-amylase and anxiety state in the cGxE effect were found. 30192917 2019
Entrez Id: 277
Gene Symbol: AMY1B
AMY1B
0.020 Biomarker disease BEFREE Immediately before and after a mindfulness session, participants completed questionnaires to assess the short-term effects on mood and state anxiety and provided saliva samples to assess salivary alpha amylase (sAA) concentrations. 30395806 2019
Entrez Id: 277
Gene Symbol: AMY1B
AMY1B
0.020 Biomarker disease BEFREE No mediating roles of salivary alpha-amylase and anxiety state in the cGxE effect were found. 30192917 2019
Entrez Id: 278
Gene Symbol: AMY1C
AMY1C
0.020 Biomarker disease BEFREE No mediating roles of salivary alpha-amylase and anxiety state in the cGxE effect were found. 30192917 2019
Entrez Id: 278
Gene Symbol: AMY1C
AMY1C
0.020 Biomarker disease BEFREE Immediately before and after a mindfulness session, participants completed questionnaires to assess the short-term effects on mood and state anxiety and provided saliva samples to assess salivary alpha amylase (sAA) concentrations. 30395806 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.010 Biomarker disease BEFREE It is not known whether apolipoprotein E ε4-an Alzheimer disease susceptibility gene-influences the effects of state-anxiety on executive functioning in healthy individuals. 21948890 2011
Entrez Id: 351
Gene Symbol: APP
APP
0.300 Biomarker disease CTD_human Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice. 19664757 2010
Entrez Id: 340075
Gene Symbol: ARSI
ARSI
0.010 GeneticVariation disease BEFREE The authors evaluated depression (Allgemeine Depressionsskala K score) and anxiety (Post-Traumatic Stress Scale-10 [PTSS-10]; State Trait Anxiety Inventory-State Anxiety and -Trait Anxiety [STAI-S and STAI-T]; and Anxiety Sensitivity Index-3 [ASI-3]) scores before surgery and at 3 and 12 months after surgery. 30641847 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.020 GeneticVariation disease BEFREE In family-based analysis, one single-nucleotide polymorphism (SNP; rs1143629, interleukin ( IL1B) 1β) was associated with observed child distress at Bonferroni-corrected levels of significance ( p = .00013), while two approached significance for association with high state anxiety (rs6330 Nerve Growth Factor, Beta Subunit, [ NGFB]) and high trait anxiety (rs6265 brain-derived neurotrophic factor [ BDNF]). 28413930 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.020 Biomarker disease BEFREE In this study, we found that music treatment could significantly decrease anxiety state in BDNF(Met/Met) mice, but not in BDNF(+/)(-), mice compared with white noise exposure in open field and elevated plus maze test. 20515664 2010
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.300 Biomarker disease CTD_human Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood. 28696432 2018
Entrez Id: 9607
Gene Symbol: CARTPT
CARTPT
0.300 Biomarker disease CTD_human Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents. 12600694 2003
Entrez Id: 1055
Gene Symbol: CECR
CECR
0.010 Biomarker disease BEFREE There was a significant decrease in depression (CES-D and PHQ-9, <i>p</i> < 0.001) and anxiety (state and trait, <i>p</i> < 0.001). 29082262 2017
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
0.300 Biomarker disease CTD_human Progesterone modulation of alpha5 nAChR subunits influences anxiety-related behavior during estrus cycle. 19220484 2009
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
0.300 Biomarker disease CTD_human Knockout of alpha 5 nicotinic acetylcholine receptors subunit alters ethanol-mediated behavioral effects and reward in mice. 29944862 2018
Entrez Id: 1141
Gene Symbol: CHRNB2
CHRNB2
0.300 Biomarker disease CTD_human The β2 nicotinic acetylcholine receptor subunit differentially influences ethanol behavioral effects in the mouse. 23419392 2013
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.300 Biomarker disease CTD_human Chronic unpredictable stress enhances cocaine-conditioned place preference in type 1 cannabinoid receptor knockout mice. 18690112 2008
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.300 Biomarker disease CTD_human Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors. 15081793 2004
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.010 Biomarker disease BEFREE Additionally, MT-ND6 was associated with the maternal psychosocial stress in pregnancy index of Prenatal Perceived Stress (β = -0.231; p-regression = 0.004; r2-regression = 0.120), while MT-CO2 was associated with the maternal psychosocial stress in pregnancy indices of State Anxiety (β = 0.206; p-regression = 0.003; r2-regression = 0.153) and Trait Anxiety (β = 0.205; p-regression = 0.003; r2-regression = 0.129). 26418562 2015
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.300 Biomarker disease CTD_human Neuropeptide Y Y1 receptor-mediated anxiolysis in the dorsocaudal lateral septum: functional antagonism of corticotropin-releasing hormone-induced anxiety. 11440811 2001