Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A 		0.400 FusionGene disease ORPHANET
Entrez Id: 5087
Gene Symbol: PBX1
PBX1 		0.400 FusionGene disease ORPHANET
Entrez Id: 6929
Gene Symbol: TCF3
TCF3 		0.360 FusionGene disease ORPHANET
Entrez Id: 4299
Gene Symbol: AFF1
AFF1 		0.320 FusionGene disease ORPHANET
Entrez Id: 933
Gene Symbol: CD22
CD22 		0.100 Biomarker disease BEFREE (90) Y-Epratuzumab tetraxetan may be a promising therapeutic option for CD22(+) B-ALL patients. 23927500 2013
Entrez Id: 388585
Gene Symbol: HES5
HES5 		0.010 PosttranslationalModification disease BEFREE 5-aza-2'-deoxycytidine treatment restored Hes5 expression and decreased promoter hypermethylation in most leukemia cell lines and primary B-ALL samples. 23637910 2013
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A 		0.400 AlteredExpression disease BEFREE Pro-B-cell to pre-B-cell development in B-lineage acute lymphoblastic leukemia expressing the MLL/AF4 fusion protein. 11719380 2001
Entrez Id: 3492
Gene Symbol: IGH
IGH 		0.400 GeneticVariation disease BEFREE B-precursor ALL cases (especially stage IV of Nadler's criteria) have V-D-J rearranged IgH genes on both alleles. 1405717 1992
Entrez Id: 406947
Gene Symbol: MIR155
MIR155 		0.030 Biomarker disease BEFREE Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. 16641092 2006
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1 		0.400 Biomarker disease BEFREE Pre-B cell receptor-mediated cell cycle arrest in Ph(+) ALL cells critically depends on IKAROS function, and is reversed by coexpression of the dominant-negative IKAROS splice variant IK6. 19620627 2009
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.400 AlteredExpression disease BEFREE Pro B (p=0.04) and pre B (p=0.04) patients showed significantly high PAX5 mRNA levels compared to stage specific controls. 21813177 2012
Entrez Id: 7037
Gene Symbol: TFRC
TFRC 		0.010 AlteredExpression disease BEFREE B-cell acute lymphoblastic leukemia (B-ALL) expressed low levels of CD71 on leukemic cells, significantly lower than AML, mixed phenotype acute leukemia (MPAL) and normal bone marrow blasts (p < 0.05). 23962073 2014
Entrez Id: 3492
Gene Symbol: IGH
IGH 		0.400 GeneticVariation disease BEFREE B acute lymphoblastic leukemia with t(14;19)(q32;p13.1) involving IGH/EPOR: a clinically aggressive subset of disease. 24030742 2014
Entrez Id: 2057
Gene Symbol: EPOR
EPOR 		0.010 GeneticVariation disease BEFREE B acute lymphoblastic leukemia with t(14;19)(q32;p13.1) involving IGH/EPOR: a clinically aggressive subset of disease. 24030742 2014
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.020 Biomarker disease BEFREE Pre-B cell colony-enhancing factor (PBEF) is a highly conserved pleiotropic protein reported to be an alternate ligand for the insulin receptor (IR). 25516545 2015
Entrez Id: 5452
Gene Symbol: POU2F2
POU2F2 		0.010 AlteredExpression disease BEFREE Oct-2 gene was expressed in 82% of pre-B ALL and all B-CLL samples. 10905058 2000
Entrez Id: 6582
Gene Symbol: SLC22A2
SLC22A2 		0.010 AlteredExpression disease BEFREE Oct-2 gene was expressed in 82% of pre-B ALL and all B-CLL samples. 10905058 2000
Entrez Id: 931
Gene Symbol: MS4A1
MS4A1 		0.050 AlteredExpression disease BEFREE CD20 is a B-cell-restricted antigen that, for the most part, is expressed from the pre-B-cell to the mature B-cell stage of B-cell differentiation. 11226004 2000
Entrez Id: 54474
Gene Symbol: KRT20
KRT20 		0.050 AlteredExpression disease BEFREE CD20 is a B-cell-restricted antigen that, for the most part, is expressed from the pre-B-cell to the mature B-cell stage of B-cell differentiation. 11226004 2000
Entrez Id: 997
Gene Symbol: CDC34
CDC34 		0.010 AlteredExpression disease BEFREE CDC34 protein (but not mRNA) was also increased in T-cell ALL compared with pre-B-cell ALL cell lines. 11504708 2001
Entrez Id: 2120
Gene Symbol: ETV6
ETV6 		0.400 GeneticVariation disease BEFREE TEL is frequently disrupted by chromosomal translocations such as the t(12;21), which is associated with nearly one-fourth of pediatric B cell acute lymphoblastic leukemia. 12626745 2003
Entrez Id: 930
Gene Symbol: CD19
CD19 		0.100 Biomarker disease BEFREE CD19 negative precursor B acute lymphoblastic leukemia presenting with hypercalcemia. 15170892 2004
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3 		0.010 Biomarker disease BEFREE Smad3 protein was absent in T-cell ALL but present in pre-B-cell ALL and ANLL. 15295048 2004
Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70 		0.040 AlteredExpression disease BEFREE ZAP-70 was constitutively expressed and phosphorylated on tyr319 in human precursor Blin-ALL cell lines as well as in primary B leukemic cells from all examined Blin-ALL patients with pro-B, pre-B and B phenotypes, but not in malignant myeloid cells. 15996927 2005
Entrez Id: 29760
Gene Symbol: BLNK
BLNK 		0.070 Biomarker disease BEFREE SLP65 represents a critical component in (pre-) B cell receptor signal transduction but is compromised in a subset of pre-B cell-derived acute lymphoblastic leukemia. 16568084 2006