Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 442206
Gene Symbol: GPR166P
GPR166P 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA 		0.010 GeneticVariation disease BEFREE All 10 tumors had low (less than or equal to 2 mutations/Megabase) TMB indicating a potential trend between G protein-coupled receptor (GPCR) alterations and low TMB in LMNs. 31663661 2019
Entrez Id: 9170
Gene Symbol: LPAR2
LPAR2 		0.010 GeneticVariation disease BEFREE All 10 tumors had low (less than or equal to 2 mutations/Megabase) TMB indicating a potential trend between G protein-coupled receptor (GPCR) alterations and low TMB in LMNs. 31663661 2019
Entrez Id: 148
Gene Symbol: ADRA1A
ADRA1A 		0.010 GeneticVariation disease BEFREE All 10 tumors had low (less than or equal to 2 mutations/Megabase) TMB indicating a potential trend between G protein-coupled receptor (GPCR) alterations and low TMB in LMNs. 31663661 2019
Entrez Id: 117196
Gene Symbol: MRGPRX4
MRGPRX4 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 2866
Gene Symbol: GPR42
GPR42 		0.010 GeneticVariation disease BEFREE All 10 tumors had low (less than or equal to 2 mutations/Megabase) TMB indicating a potential trend between G protein-coupled receptor (GPCR) alterations and low TMB in LMNs. 31663661 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.010 Biomarker disease BEFREE We present the case of a 16-year-old boy with NCM who developed malignant leptomeningeal melanoma following immunosuppression with a TNFα inhibitor. 30868657 2019
Entrez Id: 6754
Gene Symbol: SSTR4
SSTR4 		0.010 GeneticVariation disease BEFREE All 10 tumors had low (less than or equal to 2 mutations/Megabase) TMB indicating a potential trend between G protein-coupled receptor (GPCR) alterations and low TMB in LMNs. 31663661 2019
Entrez Id: 222545
Gene Symbol: GPRC6A
GPRC6A 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 23566
Gene Symbol: LPAR3
LPAR3 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 117195
Gene Symbol: MRGPRX3
MRGPRX3 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 59352
Gene Symbol: LGR6
LGR6 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 151
Gene Symbol: ADRA2B
ADRA2B 		0.010 GeneticVariation disease BEFREE All 10 tumors had low (less than or equal to 2 mutations/Megabase) TMB indicating a potential trend between G protein-coupled receptor (GPCR) alterations and low TMB in LMNs. 31663661 2019
Entrez Id: 165140
Gene Symbol: OXER1
OXER1 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3 		0.010 GeneticVariation disease BEFREE All 10 tumors had low (less than or equal to 2 mutations/Megabase) TMB indicating a potential trend between G protein-coupled receptor (GPCR) alterations and low TMB in LMNs. 31663661 2019
Entrez Id: 134391
Gene Symbol: GPR151
GPR151 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 10663
Gene Symbol: CXCR6
CXCR6 		0.010 GeneticVariation disease BEFREE All 10 tumors had low (less than or equal to 2 mutations/Megabase) TMB indicating a potential trend between G protein-coupled receptor (GPCR) alterations and low TMB in LMNs. 31663661 2019
Entrez Id: 441931
Gene Symbol: VN1R17P
VN1R17P 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 259249
Gene Symbol: MRGPRX1
MRGPRX1 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 8322
Gene Symbol: FZD4
FZD4 		0.010 GeneticVariation disease BEFREE GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset. 31663661 2019
Entrez Id: 680
Gene Symbol: BRS3
BRS3 		0.010 GeneticVariation disease BEFREE All 10 tumors had low (less than or equal to 2 mutations/Megabase) TMB indicating a potential trend between G protein-coupled receptor (GPCR) alterations and low TMB in LMNs. 31663661 2019
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.010 GeneticVariation disease BEFREE NRAS(Q61K) mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications. 27439913 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.010 GeneticVariation disease BEFREE Prolonged survival of a patient with metastatic leptomeningeal melanoma treated with BRAF inhibition-based therapy: a case report. 25962795 2015