Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10848
Gene Symbol: PPP1R13L
PPP1R13L
0.100 Biomarker disease BEFREE <b>Abbreviations: BM</b> = bone metastases; <b>COX</b> = multivariate analyses; <b>DM</b> = distant metastases; <b>DSM</b> = disease-specific mortality; <b>DSS</b> = disease-specific survival; <b>DTC</b> = differentiated thyroid carcinoma; <b>ETE</b> = extrathyroidal extension; <b>LNM</b> = lymph node metastases; <b>OM</b> = overall mortality; <b>OS</b> = overall survival; <b>PTCFV</b> = papillary thyroid carcinoma; <b>RAI</b> = radioactive iodine; <b>SM</b> = spinal metastases; <b>SRE</b> = skeletal-related event; <b>txWBS</b> = whole-body scan after RAI therapy. 30657361 2019
Entrez Id: 53358
Gene Symbol: SHC3
SHC3
0.100 Biomarker disease BEFREE <b>Abbreviations: BM</b> = bone metastases; <b>COX</b> = multivariate analyses; <b>DM</b> = distant metastases; <b>DSM</b> = disease-specific mortality; <b>DSS</b> = disease-specific survival; <b>DTC</b> = differentiated thyroid carcinoma; <b>ETE</b> = extrathyroidal extension; <b>LNM</b> = lymph node metastases; <b>OM</b> = overall mortality; <b>OS</b> = overall survival; <b>PTCFV</b> = papillary thyroid carcinoma; <b>RAI</b> = radioactive iodine; <b>SM</b> = spinal metastases; <b>SRE</b> = skeletal-related event; <b>txWBS</b> = whole-body scan after RAI therapy. 30657361 2019
Entrez Id: 2657
Gene Symbol: GDF1
GDF1
0.100 Biomarker disease BEFREE <b>Abbreviations: BM</b> = bone metastases; <b>COX</b> = multivariate analyses; <b>DM</b> = distant metastases; <b>DSM</b> = disease-specific mortality; <b>DSS</b> = disease-specific survival; <b>DTC</b> = differentiated thyroid carcinoma; <b>ETE</b> = extrathyroidal extension; <b>LNM</b> = lymph node metastases; <b>OM</b> = overall mortality; <b>OS</b> = overall survival; <b>PTCFV</b> = papillary thyroid carcinoma; <b>RAI</b> = radioactive iodine; <b>SM</b> = spinal metastases; <b>SRE</b> = skeletal-related event; <b>txWBS</b> = whole-body scan after RAI therapy. 30657361 2019
Entrez Id: 6050
Gene Symbol: RNH1
RNH1
0.100 Biomarker disease BEFREE <b>Abbreviations: BM</b> = bone metastases; <b>COX</b> = multivariate analyses; <b>DM</b> = distant metastases; <b>DSM</b> = disease-specific mortality; <b>DSS</b> = disease-specific survival; <b>DTC</b> = differentiated thyroid carcinoma; <b>ETE</b> = extrathyroidal extension; <b>LNM</b> = lymph node metastases; <b>OM</b> = overall mortality; <b>OS</b> = overall survival; <b>PTCFV</b> = papillary thyroid carcinoma; <b>RAI</b> = radioactive iodine; <b>SM</b> = spinal metastases; <b>SRE</b> = skeletal-related event; <b>txWBS</b> = whole-body scan after RAI therapy. 30657361 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE <b>Background:</b> In patients with differentiated thyroid cancer (DTC) and raising serum thyroglobulin (Tg) after total or near-total thyroidectomy and <sup>131</sup>I remnant ablation an empiric <sup>131</sup>I therapy may be considered. 30930852 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE <b>Background:</b> Patients treated for intermediate- or high-risk differentiated thyroid carcinoma (DTC) and Thyroglobulin (TG) elevation during follow-up, require a diagnostic whole-body scan (DWBS) and if positive, <sup>131</sup>I treatment. 31736875 2019
Entrez Id: 140805
Gene Symbol: HT
HT
0.020 GeneticVariation disease BEFREE <b>Methods:</b> The SNP's <i>FOXO3a</i> rs4946936/rs4945816/rs9400239 were genotyped in 257 patients with differentiated thyroid carcinoma (DTC), 139 patients with Hashimoto thyroiditis (HT) and 463 healthy controls (HC). 30271381 2018
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.100 Biomarker disease BEFREE <sup>18</sup>FDG PET/CT is crucial before neck surgery for nodal recurrence localization in iodine-refractory differentiated or poorly differentiated thyroid cancer (DTC/PDTC). 30511173 2018
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.100 Biomarker disease BEFREE <sup>18</sup>F-FDG positive metastatic DTC with SUVmax of greater than 4.0 possesses higher probability of non-avidity to radioiodine. 29531251 2018
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.100 Biomarker disease BEFREE <sup>18</sup>F-FDG PET/CT and ultrasonogrpahy in differentiated thyroid carcinoma patients with elevated serum levels of antithyroglobulin antibody, negative Tg and whole body <sup>131</sup>I scan. 29550843 2018
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 AlteredExpression disease BEFREE <sup>99m</sup>Tc-sestamibi may have a role in thyroid cancer localization when physical exam, neck ultrasound, radioiodine scan, chest/abdomen CT, and <sup>18</sup>F-FDG PET/CT does not identify the source of elevated Tg levels in DTC. 29797211 2018
Entrez Id: 3111
Gene Symbol: HLA-DOA
HLA-DOA
0.010 Biomarker disease BEFREE Well differentiated thyroid carcinoma is associated with human lymphocyte antigen D-related 11 in Eastern Hungarians: a case of changing circumstances. 16121403 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.020 Biomarker disease BEFREE Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A. 17158762 2006
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.010 Biomarker disease BEFREE Well-differentiated thyroid cancer with a minor poorly differentiated component: clonal heterogeneity through the prognostic role of CXCR4 and BRAF analysis. 24992171 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation disease BEFREE Well-differentiated thyroid cancer with a minor poorly differentiated component: clonal heterogeneity through the prognostic role of CXCR4 and BRAF analysis. 24992171 2015
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Differentiated thyroid cancer (DTC) patients with negative serum thyroglobulin (Tg), negative <sup>131</sup>I whole-body scintigraphy (<sup>131</sup>I-WBS) at first post-ablation and progressively increased TgAb level are a relatively rare entity in the follow-up after total thyroidectomy and radioactive iodine therapy. 28588229 2017
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Differentiated thyroid cancer (DTC) with thyroglobulin elevation and negative I scintigraphy (TENIS) syndrome is a diagnostic and therapeutic dilemma. 30080688 2018
Entrez Id: 9170
Gene Symbol: LPAR2
LPAR2
0.020 AlteredExpression disease BEFREE EDG4 receptor mRNA expression was increased 3-fold in differentiated thyroid cancer (p < 0.01), both papillary (p < 0.01) and follicular (p < 0.05), compared to normal thyroid or goiter. 11291053 2001
Entrez Id: 2869
Gene Symbol: GRK5
GRK5
0.010 AlteredExpression disease BEFREE GRK5 protein expression was significantly decreased in differentiated thyroid carcinoma (P < 0.02) and paralleled a decrease in GRK mRNA expression (P < 0.02). 12107237 2002
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.010 Biomarker disease BEFREE HLA-C genotyping was performed in 63 patients undergoing surgery for differentiated thyroid carcinoma (57 patients with the papillary subtype and 6 patients with the follicular subtype). 14716759 2004
Entrez Id: 754
Gene Symbol: PTTG1IP
PTTG1IP
0.030 Biomarker disease BEFREE PBF is an additional prognostic indicator in differentiated thyroid cancer that is transforming in vitro and tumorigenic in vivo. 15886233 2005
Entrez Id: 55893
Gene Symbol: ZNF395
ZNF395
0.030 Biomarker disease BEFREE PBF is an additional prognostic indicator in differentiated thyroid cancer that is transforming in vitro and tumorigenic in vivo. 15886233 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.020 Biomarker disease BEFREE Epidermal growth factor receptor and ephrin B2 are markers of aggressive differentiated thyroid cancer. 16360397 2005
Entrez Id: 4176
Gene Symbol: MCM7
MCM7
0.010 AlteredExpression disease BEFREE MCM7 mRNA expression is higher in locally invasive differentiated thyroid cancer. 16547620 2006
Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
0.100 Biomarker disease BEFREE NIS offers the unique advantage that it can be used both as a reporter and as a therapeutic gene, so that it is possible to image, monitor, and treat the tumor with radioiodide, just as in differentiated thyroid cancer. 16990649 2006