Gene: PIK3CA ×
Source: INFERRED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 GeneticVariation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 GeneticVariation group CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system. 23888070 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials. 23066039 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. 22162589 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials. 22162582 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. 21558396 2011
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models. 20453058 2010
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. 18725974 2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. 18676830 2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. 15647370 2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR We identified PIK3CA mutations in 26% of 342 human breast tumor samples and cell lines at about equal frequency in tumor stages I to IV. 15805248 2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 GeneticVariation group CLINVAR We identified PIK3CA mutations in 26% of 342 human breast tumor samples and cell lines at about equal frequency in tumor stages I to IV. 15805248 2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.500 CausalMutation group CLINVAR The PIK3CA gene is mutated with high frequency in human breast cancers. 15254419 2004