The present study investigated a new treatment model for evaluating the US-mediated liquid-type epidermal growth factor (EGF)-coated lysozyme microbubble (LYMB) cavitation in a wound dressing for enhancing wound healing.
Nine different proteins (α-lactalbumin, two antibodies, fibroblast growth factor 2, granulocyte colony stimulating factor [GCSF], green fluorescence protein [GFP], hemoglobin, human serum albumin, and lysozyme) are tested for their aggregation behavior on vapor/liquid interfaces generated by cavitation and compared it to the isolated effects of high shear stress and air/liquid interfaces generated by foaming.
The present study investigated a new treatment model for evaluating the antibacterial effects of lysozyme (LY)-shelled microbubbles (MBs) and ultrasound (US)-mediated LY-shelled MBs cavitation against P. acnes both in vitro and in vivo, with the aims of reducing the dose and treatment duration and improving the prognosis of acne vulgaris.
Multivariable models showed that serum albumin decreased significantly as the percentage of lung field area increased in both those with and without cavitation.
Nine different proteins (α-lactalbumin, two antibodies, fibroblast growth factor 2, granulocyte colony stimulating factor [GCSF], green fluorescence protein [GFP], hemoglobin, human serum albumin, and lysozyme) are tested for their aggregation behavior on vapor/liquid interfaces generated by cavitation and compared it to the isolated effects of high shear stress and air/liquid interfaces generated by foaming.
In this study, ultrasound-mediated cavitation of microbubbles was investigated as a mean of enhancing the delivery of a liposome designed for chemo-radionuclide therapy targeted to EGFR overexpressing cancer.
We speculate that according to physical models closing of the tubular tracheal network provokes initial increase of the internal hydrostatic pressure necessary for gas generation through cavitation when the pressure is subsequently decreased.
We speculate that according to physical models closing of the tubular tracheal network provokes initial increase of the internal hydrostatic pressure necessary for gas generation through cavitation when the pressure is subsequently decreased.
We speculate that according to physical models closing of the tubular tracheal network provokes initial increase of the internal hydrostatic pressure necessary for gas generation through cavitation when the pressure is subsequently decreased.
Such a hybrid nanoreactor exhibited sensitive catalytic activity toward H<sub>2</sub>O<sub>2</sub>, facilitating the continuous O<sub>2</sub> gas generation in a relatively mild manner even if incubated with 10 μM H<sub>2</sub>O<sub>2</sub>, which finally led to enhanced ablation in the tissue-mimicking PAA gel model after HIFU exposure mainly resulting from intensified cavitation effect.
Thus whereas pMLKL-driven necroptosis does not appear to be a feature of M. tuberculosis-infected macrophage cell death, it may contribute to TNFα-induced cytotoxicity of the lung stroma and therefore contribute to necrotic cavitation and bacterial dissemination.
Such a hybrid nanoreactor exhibited sensitive catalytic activity toward H<sub>2</sub>O<sub>2</sub>, facilitating the continuous O<sub>2</sub> gas generation in a relatively mild manner even if incubated with 10 μM H<sub>2</sub>O<sub>2</sub>, which finally led to enhanced ablation in the tissue-mimicking PAA gel model after HIFU exposure mainly resulting from intensified cavitation effect.
Such a hybrid nanoreactor exhibited sensitive catalytic activity toward H<sub>2</sub>O<sub>2</sub>, facilitating the continuous O<sub>2</sub> gas generation in a relatively mild manner even if incubated with 10 μM H<sub>2</sub>O<sub>2</sub>, which finally led to enhanced ablation in the tissue-mimicking PAA gel model after HIFU exposure mainly resulting from intensified cavitation effect.
After chemotherapy, abdominal cavity tumor growth inhibition rate was higher in BCT group (67%) compared to ADM and TNF groups, and similar to HepG(2) group (54%).
Addition of PS20 to formulations in glass and silicone oil-coated glass vials significantly reduced both incidence of mechanical shock-induced cavitation, and the particle formation that resulted from cavitation events.
Subsequently, GSH-triggered MnO degradation simultaneously released smaller Au NPs as numerous cavitation nucleation sites and Mn<sup>2+</sup> for chemodynamic therapy (CDT), resulting in enhanced reactive oxygen species (ROS) generation.
Compared with ALK-negative NSCLC, ALK-rearranged NSCLC was more likely to be solid (OR, 2.37; P < .001) and less likely to have cavitation (OR, 0.45; P = .002).
While lower baseline MD of the RSSI (r<sub>s</sub> = - 0.371; p = 0.004) and more contrast leakage into CSF (r<sub>s</sub> = 0.347; p = 0.007) were associated with the cavitation index in univariable analysis, only BBB leakage in CSF remained independently associated with cavitation (beta = 0.315, p = 0.046).
Using 24-38 kDa PLGA and 1.0% PVA, we obtained by cavitation NPs with hydrodynamic diameter of 384 nm, polydispersity index of 0.143 and Zeta potential of -16.4 mV, whose ASNase encapsulation efficiency was as high as 87 ± 2%.
We show that Col22a1, a marker of early articular chondrocytes, is co-expressed with Lgr5<sup>+</sup> cells prior to cavitation as an important lineage marker specifying the progression toward articular chondrocytes.
While lower baseline MD of the RSSI (r<sub>s</sub> = - 0.371; p = 0.004) and more contrast leakage into CSF (r<sub>s</sub> = 0.347; p = 0.007) were associated with the cavitation index in univariable analysis, only BBB leakage in CSF remained independently associated with cavitation (beta = 0.315, p = 0.046).