×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
BEFREE
While for patients with Parkinsonism, GCH1 mutation analysis should be performed after screening of genes like PARKIN, PARK7 (DJ-1 ) and PINK1.
27619486
2017
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
CTD_human
BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage.
28348719
2017
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
BEFREE
Several mutated genes have been found in familial PD patients, including SNCA (α-synuclein), PARK2 (parkin), PINK1, PARK7 (DJ-1 ), LRRK2 and ATP13A2 Many pathogenic mutations of PARK2, which encodes the ubiquitin E3 ligase parkin, result in loss of function, leading to accumulation of parkin substrates and consequently contributing to dopaminergic cell death.
27534820
2016
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
BEFREE
PARK2, PINK1 and PARK7 (DJ-1 ), have been identified as responsible for the autosomal recessive form of early-onset Parkinson disease (EO-PD).
23986421
2013
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
UNIPROT
Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity.
23792957
2013
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
UNIPROT
DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes.
23847046
2013
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
MGD
Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease.
23019375
2012
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
BEFREE
We screened 136 EOPD probands from a high-ascertainment regional and community-based prevalence study for pathogenic mutations in PARK2 (parkin), PINK1, PARK7 (DJ-1 ), and exon 41 of LRRK2.
22956510
2012
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
UNIPROT
Human DJ-1 and its homologs are novel glyoxalases.
22523093
2012
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
UNIPROT
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.
19229105
2009
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
MGD
Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.
18187333
2008
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
UNIPROT
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.
17846173
2007
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
MGD
Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice.
17535435
2007
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
MGD
Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice.
15799973
2005
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
MGD
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.
15784737
2005
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
MGD
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1.
15721235
2005
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
UNIPROT
Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1.
14607841
2004
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
BEFREE
Analyzing the PARK7 /DJ1 gene in 104 EOPD patients, we identified a third mutation, c.192G>C (p.E64D ), associated with EOPD in a patient of Turkish ancestry and characterized the functional significance of this amino acid substitution.
15365989
2004
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
UNIPROT
Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations.
15254937
2004
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
UNIPROT
Analyzing the PARK7 /DJ1 gene in 104 EOPD patients, we identified a third mutation, c.192G>C (p.E64D), associated with EOPD in a patient of Turkish ancestry and characterized the functional significance of this amino acid substitution.
15365989
2004
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
BEFREE
Finally it was confirmed that PARK6 and PARK7 (DJ-1 ), despite being phenotypically similar and mapping to the same small chromosomal region of 1p36, are caused by mutations in separate genes.
14707326
2004
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
BEFREE
To date, genetic analyses have detected linkage to six chromosomal regions and have identified three causative genes: PARK1 (alpha-synuclein), PARK2 (parkin), and PARK7 (DJ-1 ).
15717024
2004
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
UNIPROT
The role of pathogenic DJ-1 mutations in Parkinson's disease.
12953260
2003
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
Biomarker
disease
GENOMICS_ENGLAND
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.
12446870
2003
×
Entrez Id:
11315
Gene Symbol:
PARK7
PARK7
0.970
GeneticVariation
disease
UNIPROT
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system.
12851414
2003