Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1 		0.100 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 25
Gene Symbol: ABL1
ABL1 		0.100 GeneticVariation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 25
Gene Symbol: ABL1
ABL1 		0.100 GeneticVariation disease CLINVAR MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. 22772060 2013
Entrez Id: 64109
Gene Symbol: CRLF2
CRLF2 		0.100 CausalMutation disease CLINVAR Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study. 22368272 2012
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.100 CausalMutation disease CLINVAR Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. 22955920 2012
Entrez Id: 3575
Gene Symbol: IL7R
IL7R 		0.100 GeneticVariation disease CLINVAR Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. 22897847 2012
Entrez Id: 3716
Gene Symbol: JAK1
JAK1 		0.100 GeneticVariation disease CLINVAR Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. 22955920 2012
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.100 CausalMutation disease CLINVAR Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. 22368270 2012
Entrez Id: 3575
Gene Symbol: IL7R
IL7R 		0.100 GeneticVariation disease CLINVAR Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. 22955920 2012
Entrez Id: 3716
Gene Symbol: JAK1
JAK1 		0.100 GeneticVariation disease CLINVAR Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. 21680795 2011
Entrez Id: 64109
Gene Symbol: CRLF2
CRLF2 		0.100 CausalMutation disease CLINVAR Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia. 19907440 2010
Entrez Id: 64109
Gene Symbol: CRLF2
CRLF2 		0.100 CausalMutation disease CLINVAR Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. 20018760 2010
Entrez Id: 64109
Gene Symbol: CRLF2
CRLF2 		0.100 CausalMutation disease CLINVAR Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. 19965641 2010
Entrez Id: 3716
Gene Symbol: JAK1
JAK1 		0.100 GeneticVariation disease CLINVAR ALL-associated JAK1 mutations confer hypersensitivity to the antiproliferative effect of type I interferon. 20167706 2010
Entrez Id: 3716
Gene Symbol: JAK1
JAK1 		0.100 GeneticVariation disease CLINVAR Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers. 19139102 2009
Entrez Id: 3716
Gene Symbol: JAK1
JAK1 		0.100 GeneticVariation disease CLINVAR JAK mutations in high-risk childhood acute lymphoblastic leukemia. 19470474 2009
Entrez Id: 3716
Gene Symbol: JAK1
JAK1 		0.100 GeneticVariation disease CLINVAR Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. 19838194 2009
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.100 CausalMutation disease CLINVAR JAK mutations in high-risk childhood acute lymphoblastic leukemia. 19470474 2009
Entrez Id: 25
Gene Symbol: ABL1
ABL1 		0.100 GeneticVariation disease CLINVAR Kinase domain point mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia emerge after therapy with BCR-ABL kinase inhibitors. 18615627 2008
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.100 CausalMutation disease CLINVAR Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. 18805579 2008
Entrez Id: 25
Gene Symbol: ABL1
ABL1 		0.100 GeneticVariation disease CLINVAR Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. 11861307 2002
Entrez Id: 25
Gene Symbol: ABL1
ABL1 		0.100 GeneticVariation disease CLINVAR BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. 11853795 2002
Entrez Id: 4507
Gene Symbol: MTAP
MTAP 		0.010 GeneticVariation disease BEFREE These findings indicate that loss of chromosomal material in the region of 9p21-p22 is closely associated with lymphomatous ALL; by analogy with retinoblastoma, in which gene deletions are associated with an enzyme deficiency, this disease may be related to the loss of the enzyme methylthioadenosine phosphorylase, previously reported in some of these patients. 3925340 1985