×
Entrez Id:
5291
Gene Symbol:
PIK3CB
PIK3CB
0.020
Biomarker
disease
BEFREE
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K /Akt/GSK3β Pathway.
30175975
2018
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
0.020
Biomarker
disease
BEFREE
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K /Akt/GSK3β Pathway.
30175975
2018
×
Entrez Id:
5293
Gene Symbol:
PIK3CD
PIK3CD
0.020
Biomarker
disease
BEFREE
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K /Akt/GSK3β Pathway.
30175975
2018
×
Entrez Id:
5294
Gene Symbol:
PIK3CG
PIK3CG
0.020
Biomarker
disease
BEFREE
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K /Akt/GSK3β Pathway.
30175975
2018
×
Entrez Id:
2932
Gene Symbol:
GSK3B
GSK3B
0.200
Therapeutic
disease
RGD
Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3β signaling pathway.
26970304
2016
×
Entrez Id:
177
Gene Symbol:
AGER
AGER
0.200
Therapeutic
disease
RGD
Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats.
24291733
2014
×
Entrez Id:
5468
Gene Symbol:
PPARG
PPARG
0.200
Therapeutic
disease
RGD
Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats.
24291733
2014
×
Entrez Id:
3934
Gene Symbol:
LCN2
LCN2
0.020
Biomarker
disease
BEFREE
Corrigendum: Role of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy .
31024460
2019
×
Entrez Id:
1843
Gene Symbol:
DUSP1
DUSP1
0.200
Biomarker
disease
RGD
Expression changes of growth-associated protein-43 (GAP-43) and mitogen-activated protein kinase phosphatase-1 (MKP-1) and in hippocampus of streptozotocin-induced diabetic cognitive impairment rats.
17601561
2007
×
Entrez Id:
351
Gene Symbol:
APP
APP
0.200
Therapeutic
disease
RGD
Glucagon-Like Peptide-1 (GLP-1) Treatment Ameliorates Cognitive Impairment by Attenuating Arc Expression in Type 2 Diabetic Rats.
28885995
2017
×
Entrez Id:
177
Gene Symbol:
AGER
AGER
0.200
Therapeutic
disease
RGD
Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats.
23529380
2013
×
Entrez Id:
3934
Gene Symbol:
LCN2
LCN2
0.020
Biomarker
disease
BEFREE
Taken together, our findings highlight the critical role of LCN2 in the pathogenesis of diabetic encephalopathy .
30761088
2019
×
Entrez Id:
23411
Gene Symbol:
SIRT1
SIRT1
0.010
Biomarker
disease
BEFREE
Taken together, the present results suggest that the SIRT1 /ER stress pathway might be a crucial mechanism in the neuroprotective effect of BBR against DE .
28782427
2018
×
Entrez Id:
114548
Gene Symbol:
NLRP3
NLRP3
0.020
Biomarker
disease
BEFREE
Taken together, this study demonstrates that Gas attenuates the diabetic encephalopathy by inhibiting ER stress and NLRP3 inflammasome activation.
30544722
2018
×
Entrez Id:
1182
Gene Symbol:
CLCN3
CLCN3
0.010
Biomarker
disease
BEFREE
The CLC-3 might be modulated by TGF- beta /TGF- beta RII signaling pathway during the development of DE .
30468668
2019
×
Entrez Id:
114548
Gene Symbol:
NLRP3
NLRP3
0.020
Biomarker
disease
BEFREE
The purpose of this study was to explore the role of NLRP3 inflammasome in DEP .
29495433
2018
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.010
AlteredExpression
disease
BEFREE
The results demonstrated that Pino could suppress the nuclear translocation of NF-κB and decrease TNF-α expression in the cerebral cortex and the hippocampus of DE mice.
29150085
2018
×
Entrez Id:
2739
Gene Symbol:
GLO1
GLO1
0.010
Biomarker
disease
BEFREE
Therefore, Glo-1 and MG have been implicated in the pathogenesis of diabetic encephalopathy .
30062553
2018
×
Entrez Id:
4780
Gene Symbol:
NFE2L2
NFE2L2
0.010
Biomarker
disease
BEFREE
This study suggests that the activation of the Nrf2 -ARE signalling pathway might be a therapeutic target for the treatment of diabetic encephalopathy .
31542051
2019
×
Entrez Id:
4137
Gene Symbol:
MAPT
MAPT
0.010
Biomarker
disease
BEFREE
This study was designed to investigate the effect of metformin on hyperphosphorylated tau proteins in diabetic encephalopathy (DE ) by regulating autophagy clearance. db/db mice were randomly divided into four groups, db/+ mice were used as control group.
30219731
2019
×
Entrez Id:
5481
Gene Symbol:
PPID
PPID
0.010
Biomarker
disease
BEFREE
Thus, blockade of ATP synthase interaction with CypD provides a promising new target for therapeutic intervention in diabetic encephalopathy .
27554467
2016
×
Entrez Id:
10105
Gene Symbol:
PPIF
PPIF
0.010
Biomarker
disease
BEFREE
Thus, blockade of ATP synthase interaction with CypD provides a promising new target for therapeutic intervention in diabetic encephalopathy .
27554467
2016
×
Entrez Id:
494333
Gene Symbol:
MIR384
MIR384
0.010
AlteredExpression
disease
BEFREE
Thus, these data suggest that downregulation of miR-384 -5p in the inflammatory macrophages may enhance macrophage autophagy and contribute to the development of diabetic encephalopathy , which may be suppressed by re-expression of miR-384 -5p in macrophages.
29511445
2018
×
Entrez Id:
5293
Gene Symbol:
PIK3CD
PIK3CD
0.020
Biomarker
disease
BEFREE
Together, our data suggest that PI3k /Akt/mTOR signaling may promote the development of DE through suppression of macrophage autophagy.
30346929
2018
×
Entrez Id:
5294
Gene Symbol:
PIK3CG
PIK3CG
0.020
Biomarker
disease
BEFREE
Together, our data suggest that PI3k /Akt/mTOR signaling may promote the development of DE through suppression of macrophage autophagy.
30346929
2018