The present study revealed that a LINC01093/miR-96-5p/ZFAND5/NF-κB signaling axis may have an important role in the pathogenesis of HCC, and further investigation of this axis may provide novel insight into the development and progression of HCC.
The present study indicated that certain miRNAs (including <i>miR-96, miR-145</i> and <i>miR-183</i>) and mRNAs (including <i>NAT2, FBXO5, CCNB1, DEPDC1</i> and <i>NTN4</i>) may be associated with the effects of ribavirin on HCC.
Our data show that miR-19a and miR-96, whose expression is regulated by ANT2 suppression, were markedly upregulated in HCC cell lines and clinical samples.
Bladder cancer, lung cancer and hepatocellular carcinoma were the third most frequently reported cancer types with significant over-expression of miR-96, miR-182 and miR-183 respectively.
Suppression of miR-96 expression inhibits the invasion of HCC cells, suggesting that miR-96 may be a therapeutic target for inhibiting HCC invasion and metastasis.