HLA-DPB1
0.320
Biomarker
disease
CTD_human
HLA-DPB1 glutamate 69: a genetic marker of beryllium disease .
8105536
1993
HLA-DPB1
0.320
Biomarker
disease
BEFREE
HLA-DPB1 glutamate 69: a genetic marker of beryllium disease .
8105536
1993
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
0.310
AlteredExpression
disease
BEFREE
In patients with beryllium disease (n = 23), we observed elevated macrophage mRNA expression for TNF-alpha and IL-6 when compared with that of normal subjects (n = 7).
8179912
1994
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.310
Biomarker
disease
BEFREE
In patients with beryllium disease (n = 39), lavage fluid TNF-alpha concentration was higher than that of 16 normal subjects.
8179912
1994
×
Entrez Id:
3553
Gene Symbol:
IL1B
IL1B
0.010
AlteredExpression
disease
BEFREE
We hypothesized that alveolar macrophages and bronchoalveolar lavage fluid from patients with beryllium disease and sarcoidosis would express increased levels of mRNA and proteins, respectively, for TNF-alpha, IL-1 beta , and IL-6 compared with those of normal individuals.
8179912
1994
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
0.310
Biomarker
disease
CTD_human
Increased TNF-alpha and IL6 mRNA expression by alveolar macrophages in chronic beryllium disease.
8428540
1993
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.310
Biomarker
disease
CTD_human
Increased TNF-alpha and IL6 mRNA expression by alveolar macrophages in chronic beryllium disease.
8428540
1993
×
Entrez Id:
3559
Gene Symbol:
IL2RA
IL2RA
0.300
Biomarker
disease
CTD_human
Beryllium induces IL-2 and IFN-gamma in berylliosis.
8977230
1997
×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
0.310
GeneticVariation
disease
BEFREE
These findings may indicate that the ACE genotype is important in the immune response to beryllium and in progression to beryllium disease .
10194187
1999
×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
0.310
Biomarker
disease
CTD_human
Angiotensin-1 converting enzyme polymorphisms in chronic beryllium disease.
10194187
1999
HLA-DPB1
0.320
Biomarker
disease
CTD_human
Beryllium sensitivity is linked to HLA-DP genotype.
11551429
2001
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.310
Biomarker
disease
CTD_human
HLA-DP-unrestricted TNF-alpha release in beryllium-stimulated peripheral blood mononuclear cells.
12449171
2002
×
Entrez Id:
940
Gene Symbol:
CD28
CD28
0.300
Biomarker
disease
CTD_human
CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4+ T cells.
12952926
2003
HLA-DPB1
0.320
Biomarker
disease
CTD_human
Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease.
14662898
2003
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.310
Biomarker
disease
CTD_human
Analysis of TNF-alpha promoter polymorphisms in the susceptibility to beryllium hypersensitivity.
15127972
2004
HLA-DPB1
0.320
Biomarker
disease
CTD_human
The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitization.
15273960
2004
×
Entrez Id:
7040
Gene Symbol:
TGFB1
TGFB1
0.300
Biomarker
disease
CTD_human
Function associated transforming growth factor-beta gene polymorphism in chronic beryllium disease.
15750822
2005
HLA-DRB1
0.300
Biomarker
disease
CTD_human
Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain.
16272364
2005
HLA-DPB2
0.300
Biomarker
disease
CTD_human
Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain.
16272364
2005
HLA-DPB1
0.320
Biomarker
disease
BEFREE
Under reasonable assumptions, the longitudinal positive predictive value of the HLA-DPB1 -Glu69 marker of susceptibility to beryllium disease is 12%.
16607200
2006
×
Entrez Id:
2730
Gene Symbol:
GCLM
GCLM
0.300
Biomarker
disease
CTD_human
Chronic beryllium disease and glutathione biosynthesis genes.
16766924
2006
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.310
Biomarker
disease
CTD_human
Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease.
16980557
2007
×
Entrez Id:
7040
Gene Symbol:
TGFB1
TGFB1
0.300
Biomarker
disease
CTD_human
TGF-beta 1 variants in chronic beryllium disease and sarcoidosis.
17785866
2007
HLA-DPB1
0.320
Biomarker
disease
CTD_human
BTNL2 allele associations with chronic beryllium disease in HLA-DPB1*Glu69-negative individuals.
17927685
2007
×
Entrez Id:
56244
Gene Symbol:
BTNL2
BTNL2
0.300
Biomarker
disease
CTD_human
BTNL2 allele associations with chronic beryllium disease in HLA-DPB1*Glu69-negative individuals.
17927685
2007