Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1 		0.320 Biomarker disease CTD_human Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease. 17956852 2008
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1 		0.320 Biomarker disease CTD_human BTNL2 allele associations with chronic beryllium disease in HLA-DPB1*Glu69-negative individuals. 17927685 2007
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1 		0.320 Biomarker disease BEFREE Under reasonable assumptions, the longitudinal positive predictive value of the HLA-DPB1-Glu69 marker of susceptibility to beryllium disease is 12%. 16607200 2006
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1 		0.320 Biomarker disease CTD_human The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitization. 15273960 2004
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1 		0.320 Biomarker disease CTD_human Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. 14662898 2003
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1 		0.320 Biomarker disease CTD_human Beryllium sensitivity is linked to HLA-DP genotype. 11551429 2001
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1 		0.320 Biomarker disease CTD_human HLA-DPB1 glutamate 69: a genetic marker of beryllium disease. 8105536 1993
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1 		0.320 Biomarker disease BEFREE HLA-DPB1 glutamate 69: a genetic marker of beryllium disease. 8105536 1993
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease. 16980557 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human Analysis of TNF-alpha promoter polymorphisms in the susceptibility to beryllium hypersensitivity. 15127972 2004
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human HLA-DP-unrestricted TNF-alpha release in beryllium-stimulated peripheral blood mononuclear cells. 12449171 2002
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.310 GeneticVariation disease BEFREE These findings may indicate that the ACE genotype is important in the immune response to beryllium and in progression to beryllium disease. 10194187 1999
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.310 Biomarker disease CTD_human Angiotensin-1 converting enzyme polymorphisms in chronic beryllium disease. 10194187 1999
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.310 AlteredExpression disease BEFREE In patients with beryllium disease (n = 23), we observed elevated macrophage mRNA expression for TNF-alpha and IL-6 when compared with that of normal subjects (n = 7). 8179912 1994
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease BEFREE In patients with beryllium disease (n = 39), lavage fluid TNF-alpha concentration was higher than that of 16 normal subjects. 8179912 1994
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.310 Biomarker disease CTD_human Increased TNF-alpha and IL6 mRNA expression by alveolar macrophages in chronic beryllium disease. 8428540 1993
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.310 Biomarker disease CTD_human Increased TNF-alpha and IL6 mRNA expression by alveolar macrophages in chronic beryllium disease. 8428540 1993
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2 		0.300 Biomarker disease CTD_human BTNL2 allele associations with chronic beryllium disease in HLA-DPB1*Glu69-negative individuals. 17927685 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.300 Biomarker disease CTD_human TGF-beta 1 variants in chronic beryllium disease and sarcoidosis. 17785866 2007
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.300 Biomarker disease CTD_human BTNL2 allele associations with chronic beryllium disease in HLA-DPB1*Glu69-negative individuals. 17927685 2007
Entrez Id: 2730
Gene Symbol: GCLM
GCLM 		0.300 Biomarker disease CTD_human Chronic beryllium disease and glutathione biosynthesis genes. 16766924 2006
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.300 Biomarker disease CTD_human Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain. 16272364 2005
Entrez Id: 3116
Gene Symbol: HLA-DPB2
HLA-DPB2 		0.300 Biomarker disease CTD_human Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain. 16272364 2005
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.300 Biomarker disease CTD_human Function associated transforming growth factor-beta gene polymorphism in chronic beryllium disease. 15750822 2005
Entrez Id: 940
Gene Symbol: CD28
CD28 		0.300 Biomarker disease CTD_human CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4+ T cells. 12952926 2003