Gene: RAD51C ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 Biomarker disease GENOMICS_ENGLAND Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. 22167183 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients. 26822949 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Detecting splicing patterns in genes involved in hereditary breast and ovarian cancer. 28905878 2017
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome. 25980754 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer. 27622768 2017
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. 21990120 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase. 25292178 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Almost 2% of Spanish breast cancer families are associated to germline pathogenic mutations in the ATM gene. 27913932 2017
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR A HRM-based screening method detects RAD51C germ-line deleterious mutations in Spanish breast and ovarian cancer families. 21537932 2011
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 26261251 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease BEFREE With only one previously described homozygous RAD51C variant to date, our findings expand the phenotypic spectrum of FANCO and suggest it should be part of the antenatal differential diagnosis for trisomy 13 and 18, due to the presence of atypical findings such as cleft lip and palate, holoprosencephaly, growth restriction and overlapping fingers. 29278735 2018
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families. 25086635 2014
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 Biomarker disease GENOMICS_ENGLAND How the fanconi anemia pathway guards the genome. 19686080 2009
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Inherited Mutations in Women With Ovarian Carcinoma. 26720728 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease UNIPROT Mutation of the RAD51C gene in a Fanconi anemia-like disorder. 20400963 2010
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Veliparib Alone or in Combination with Mitomycin C in Patients with Solid Tumors With Functional Deficiency in Homologous Recombination Repair. 26848151 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Clinical Actionability of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment. 26270727 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility. 21750962 2011
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. 22006311 2011
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 Biomarker disease GENOMICS_ENGLAND Exome sequencing reveals a novel Fanconi group defined by XRCC2 mutation. 22232082 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Patterns and functional implications of rare germline variants across 12 cancer types. 26689913 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. 21990120 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Inherited Mutations in Women With Ovarian Carcinoma. 26720728 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 Biomarker disease GENOMICS_ENGLAND