×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
BEFREE
With only one previously described homozygous RAD51C variant to date, our findings expand the phenotypic spectrum of FANCO and suggest it should be part of the antenatal differential diagnosis for trisomy 13 and 18, due to the presence of atypical findings such as cleft lip and palate, holoprosencephaly, growth restriction and overlapping fingers.
29278735
2018
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
Biomarker
disease
GENOMICS_ENGLAND
With only one previously described homozygous RAD51C variant to date, our findings expand the phenotypic spectrum of FANCO and suggest it should be part of the antenatal differential diagnosis for trisomy 13 and 18, due to the presence of atypical findings such as cleft lip and palate, holoprosencephaly, growth restriction and overlapping fingers.
29278735
2018
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2.
27616075
2017
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
Detecting splicing patterns in genes involved in hereditary breast and ovarian cancer.
28905878
2017
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer.
27622768
2017
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Almost 2% of Spanish breast cancer families are associated to germline pathogenic mutations in the ATM gene.
27913932
2017
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer.
26740214
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
27433846
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
Germline mutations in DNA repair genes may predict neoadjuvant therapy response in triple negative breast patients.
27328445
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients.
26822949
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Screening for germline mutations in breast/ovarian cancer susceptibility genes in high-risk families in Israel.
26687385
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer.
26824983
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients.
26822949
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
26681312
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
Inherited Mutations in Women With Ovarian Carcinoma.
26720728
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Veliparib Alone or in Combination with Mitomycin C in Patients with Solid Tumors With Functional Deficiency in Homologous Recombination Repair.
26848151
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Inherited Mutations in Women With Ovarian Carcinoma.
26720728
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
26681312
2016
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
Clinical Actionability of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment.
26270727
2015
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
26261251
2015
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.
26057125
2015
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
25452441
2015
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
CausalMutation
disease
CLINVAR
Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.
25980754
2015
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase.
25292178
2015
×
Entrez Id:
5889
Gene Symbol:
RAD51C
RAD51C
0.710
GeneticVariation
disease
CLINVAR
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
26261251
2015