Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1 		0.020 Biomarker disease BEFREE Significant demethylation of SPINK1 was observed in eHCC compared to HGDN. 31506333 2019
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1 		0.020 Biomarker disease BEFREE SPINK1 can be used to differentiate between a WD-HCC and a HGDN with high diagnostic validity. 27028242 2018
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA 		0.010 GeneticVariation disease BEFREE Two cases (one nodule-in-nodule case and another case with closely attached HCC and HGDN) showed several overlapped driver mutations (CTNNB1 and CEBPA) and CNAs (losses of CDKN2A, RB1, and TP53) between HGDNs and HCCs, suggesting their roles in the early HCC development. 29949741 2018
Entrez Id: 6608
Gene Symbol: SMO
SMO 		0.010 Biomarker disease BEFREE Mutations in ERBB2 and CCND1, and CNAs (gains of CTNNB1, MET, and SMO and losses of PTEN, TP53, and SETD2) were identified as "HCC predominant," suggesting their roles in the progression of HGDN to HCC. 29949741 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		0.010 Biomarker disease BEFREE Two cases (one nodule-in-nodule case and another case with closely attached HCC and HGDN) showed several overlapped driver mutations (CTNNB1 and CEBPA) and CNAs (losses of CDKN2A, RB1, and TP53) between HGDNs and HCCs, suggesting their roles in the early HCC development. 29949741 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.010 GeneticVariation disease BEFREE Two cases (one nodule-in-nodule case and another case with closely attached HCC and HGDN) showed several overlapped driver mutations (CTNNB1 and CEBPA) and CNAs (losses of CDKN2A, RB1, and TP53) between HGDNs and HCCs, suggesting their roles in the early HCC development. 29949741 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.010 Biomarker disease BEFREE Mutations in ERBB2 and CCND1, and CNAs (gains of CTNNB1, MET, and SMO and losses of PTEN, TP53, and SETD2) were identified as "HCC predominant," suggesting their roles in the progression of HGDN to HCC. 29949741 2018
Entrez Id: 29072
Gene Symbol: SETD2
SETD2 		0.010 Biomarker disease BEFREE Mutations in ERBB2 and CCND1, and CNAs (gains of CTNNB1, MET, and SMO and losses of PTEN, TP53, and SETD2) were identified as "HCC predominant," suggesting their roles in the progression of HGDN to HCC. 29949741 2018
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.010 Biomarker disease BEFREE Mutations in ERBB2 and CCND1, and CNAs (gains of CTNNB1, MET, and SMO and losses of PTEN, TP53, and SETD2) were identified as "HCC predominant," suggesting their roles in the progression of HGDN to HCC. 29949741 2018