Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3977
Gene Symbol: LIFR
LIFR 		0.010 Biomarker disease BEFREE <b>Conclusions:</b> We found a highly reliable FI network, which revealed <i>LIFR, PIK3R1</i>, and <i>MMP12</i> as novel prognostic biomarker candidates for GBC. 31119098 2019
Entrez Id: 7097
Gene Symbol: TLR2
TLR2 		0.020 GeneticVariation disease BEFREE 'del' allele carriers of TLR2 (Delta22) polymorphism were associated with a 1.54-fold increased risk for GBC (95% CI=1.02-2.24; P(trend)=0.091). 20492496 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease BEFREE Gallbladder cancer does not appear associate with the R249S mutation in TP53. 28428144 2017
Entrez Id: 338
Gene Symbol: APOB
APOB 		0.030 GeneticVariation disease BEFREE Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer. 14618390 2004
Entrez Id: 2719
Gene Symbol: GPC3
GPC3 		0.010 AlteredExpression disease BEFREE GPC3 expression was downregulated in gallbladder cancer in 12 of 13 cases and the average expression level was significantly lower than that in normal gallbladder tissues (P<0.05). 16162153 2005
Entrez Id: 885
Gene Symbol: CCK
CCK 		0.050 GeneticVariation disease BEFREE Cholecystokinin receptor A gene polymorphism in gallstone disease and gallbladder cancer. 17944886 2008
Entrez Id: 9817
Gene Symbol: KEAP1
KEAP1 		0.020 GeneticVariation disease BEFREE Keap1 mutation occurs frequently in GBC. 18692501 2008
Entrez Id: 4968
Gene Symbol: OGG1
OGG1 		0.040 GeneticVariation disease BEFREE OGG1 Cys/Cys genotype frequency was significantly higher in GBC patients [odds ratio (OR) = 2.93; 95% confidence interval (CI) = 1.14-7.51]. 19266243 2009
Entrez Id: 1490
Gene Symbol: CCN2
CCN2 		0.020 AlteredExpression disease BEFREE CTGF expression was evaluated in seven GBC cell lines by Western blot assay. 23593935 2013
Entrez Id: 29128
Gene Symbol: UHRF1
UHRF1 		0.010 AlteredExpression disease BEFREE UHRF1 depletion upregulated the expression of PML and triggered extrinsic and intrinsic apoptotic pathways by promoting the expression of FasL/FADD, bax, cytosolic cytochrome c, cleaved caspase-8, -9 and -3 and cleaved PRAP and by suppressing bcl-2 expression in GBC-SD and NOZ cells. 24756644 2014
Entrez Id: 2300
Gene Symbol: FOXL1
FOXL1 		0.010 AlteredExpression disease BEFREE FOXL1 was frequently downregulated in GBC tissues and cell lines. 25010679 2014
Entrez Id: 1192
Gene Symbol: CLIC1
CLIC1 		0.040 AlteredExpression disease BEFREE CLIC1 expression was significantly higher (62.7 %) in gallbladder cancer than in cholelithiasis (21.3 %, p < 0.001). 25227665 2015
Entrez Id: 506
Gene Symbol: ATP5F1B
ATP5F1B 		0.010 Biomarker disease BEFREE ATP5b and β2-microglobulin are predictive markers for the prognosis of patients with gallbladder cancer. 25311765 2015
Entrez Id: 59272
Gene Symbol: ACE2
ACE2 		0.010 AlteredExpression disease BEFREE ACE2 levels were studied in in vivo GBC mouse models subject to ARB treatment. 25663464 2015
Entrez Id: 7439
Gene Symbol: BEST1
BEST1 		0.010 Biomarker disease BEFREE ARB blocked A2-induced GBC cell growth and activated ERK. 25663464 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		0.100 Biomarker disease BEFREE HER2/neu blockade is a promising treatment strategy for gallbladder cancer patients with gene amplification and deserves further exploration in a multi-center study. 26022204 2015
Entrez Id: 214
Gene Symbol: ALCAM
ALCAM 		0.010 GeneticVariation disease BEFREE ALCAM Ars1157Crs10511244 (P = 0.0035) haplotype was significantly associated with GBC susceptibility. 26318430 2016
Entrez Id: 4282
Gene Symbol: MIF
MIF 		0.010 Biomarker disease BEFREE Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. 26530123 2015
Entrez Id: 1236
Gene Symbol: CCR7
CCR7 		0.010 AlteredExpression disease BEFREE CCR7 was highly expressed in GBC samples. 27009073 2016
Entrez Id: 5315
Gene Symbol: PKM
PKM 		0.020 AlteredExpression disease BEFREE PKM2 mRNA level were significantly high in gallbladder cancer tissues than in adjacent noncancerous tissues (P < 0.001). 27283076 2016
Entrez Id: 112441427
Gene Symbol: GCASPC
GCASPC 		0.010 AlteredExpression disease BEFREE GCASPC levels were significantly lower in gallbladder cancer than adjacent nontumor tissues and were associated with tumor size, American Joint Committee on Cancer tumor stage, and patient outcomes. 27450454 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.010 Biomarker disease BEFREE BRAF gene amplifications were demonstrated in intrahepatic CC (4.3%), common bile duct cancer (3.3%), and gallbladder cancer (5%). 27745798 2017
Entrez Id: 407035
Gene Symbol: MIR31
MIR31 		0.010 Biomarker disease BEFREE MiR-31 regulates the cisplatin resistance by targeting Src in gallbladder cancer. 27825112 2016
Entrez Id: 7178
Gene Symbol: TPT1
TPT1 		0.020 AlteredExpression disease BEFREE TCTP is aberrantly expressed in gallbladder cancer patients and associated with metastasis and a poor prognosis. 28506239 2017
Entrez Id: 406935
Gene Symbol: MIR143
MIR143 		0.030 Biomarker disease BEFREE miR-143-5p was first found significantly reduced in GBC tissues compared with corresponding noncancerous gallbladder tissues. 28803245 2017