×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.400
GeneticVariation
disease
CLINVAR
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.400
CausalMutation
disease
CLINVAR
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.400
Biomarker
disease
CTD_human
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency.
17703371
2007
×
Entrez Id:
867
Gene Symbol:
CBL
CBL
0.100
CausalMutation
disease
CLINVAR
×
Entrez Id:
1969
Gene Symbol:
EPHA2
EPHA2
0.300
Biomarker
disease
CTD_human
Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid.
22845314
2012
×
Entrez Id:
3265
Gene Symbol:
HRAS
HRAS
0.400
Biomarker
disease
CTD_human
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency.
17703371
2007
×
Entrez Id:
3265
Gene Symbol:
HRAS
HRAS
0.400
CausalMutation
disease
CLINVAR
×
Entrez Id:
3455
Gene Symbol:
IFNAR2
IFNAR2
0.010
GeneticVariation
disease
BEFREE
Likewise, replication of G45R /NS1 virus was increased in comparison to wild type virus in both wild type and type I interferon receptor null Let1 cells.
27405392
2016
×
Entrez Id:
3456
Gene Symbol:
IFNB1
IFNB1
0.010
Biomarker
disease
BEFREE
Moreover, we found that rG66A virus induced a greater type I interferon (IFN) response than that by pSA14, and JEV NS1 ' significantly inhibited the production of IFN-β and IFN-stimulated genes.
30542978
2018
×
Entrez Id:
3600
Gene Symbol:
IL15
IL15
0.010
Biomarker
disease
BEFREE
In oncolysis sensitive melanoma cells, delNS1-IL-15 (but not delNS1 ) infection resulted in the production of IL-15 levels ranging from 70 to 1140 pg/mL in the cell culture supernatants.
22563505
2012
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
0.010
GeneticVariation
disease
BEFREE
Only weak or nonspecific binding of NS1-nuc to the segments of the TNFα and IL-6 promoters was found.
27809499
2016
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
0.300
Biomarker
disease
CTD_human
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency.
17703371
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
0.300
Biomarker
disease
CTD_human
Germline gain-of-function mutations in RAF1 cause Noonan syndrome.
17603482
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
0.300
Biomarker
disease
CTD_human
Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene.
17468812
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
0.300
Biomarker
disease
CTD_human
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.
17603483
2007
×
Entrez Id:
5604
Gene Symbol:
MAP2K1
MAP2K1
0.400
GeneticVariation
disease
CLINVAR
×
Entrez Id:
5604
Gene Symbol:
MAP2K1
MAP2K1
0.400
Biomarker
disease
CTD_human
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency.
17703371
2007
×
Entrez Id:
5604
Gene Symbol:
MAP2K1
MAP2K1
0.400
CausalMutation
disease
CLINVAR
×
Entrez Id:
5605
Gene Symbol:
MAP2K2
MAP2K2
0.300
Biomarker
disease
CTD_human
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency.
17703371
2007
×
Entrez Id:
5609
Gene Symbol:
MAP2K7
MAP2K7
0.010
Biomarker
disease
BEFREE
Interference with MEK/ERK signalling by RNAi-mediated depletion or the MEK inhibitor U0126 did not affect the oncolytic effects of the delNS1 viruses.
22563505
2012
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.400
CausalMutation
disease
CLINVAR
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.400
Biomarker
disease
CTD_human
A restricted spectrum of NRAS mutations causes Noonan syndrome.
19966803
2010
×
Entrez Id:
5920
Gene Symbol:
PLAAT4
PLAAT4
0.010
GeneticVariation
disease
BEFREE
We also observed that wild-type NS1 is capable of binding directly to the tandem RIG-I CARDs while the R21Q mutation in NS1 significantly inhibits this interaction.
31843969
2020
×
Entrez Id:
5781
Gene Symbol:
PTPN11
PTPN11
0.910
CausalMutation
disease
CLINVAR
Lethal presentation of neurofibromatosis and Noonan syndrome.
21567923
2011
×
Entrez Id:
5781
Gene Symbol:
PTPN11
PTPN11
0.910
Biomarker
disease
GENOMICS_ENGLAND
The RASopathies.
23875798
2013