Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5920
Gene Symbol: PLAAT4
PLAAT4 		0.010 GeneticVariation disease BEFREE We also observed that wild-type NS1 is capable of binding directly to the tandem RIG-I CARDs while the R21Q mutation in NS1 significantly inhibits this interaction. 31843969 2020
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1 		0.010 Biomarker disease BEFREE Moreover, we found that rG66A virus induced a greater type I interferon (IFN) response than that by pSA14, and JEV NS1' significantly inhibited the production of IFN-β and IFN-stimulated genes. 30542978 2018
Entrez Id: 6035
Gene Symbol: RNASE1
RNASE1 		0.010 Biomarker disease BEFREE To further investigate this phenomenon, we performed comparative proteomics analyses to profile host proteins in chicken embryo fibroblasts (CEFs) infected with rNS1-wt and rNS1-SD30 viruses. 29492200 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.010 GeneticVariation disease BEFREE Only weak or nonspecific binding of NS1-nuc to the segments of the TNFα and IL-6 promoters was found. 27809499 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.010 GeneticVariation disease BEFREE Only weak or nonspecific binding of NS1-nuc to the segments of the TNFα and IL-6 promoters was found. 27809499 2016
Entrez Id: 3455
Gene Symbol: IFNAR2
IFNAR2 		0.010 GeneticVariation disease BEFREE Likewise, replication of G45R/NS1 virus was increased in comparison to wild type virus in both wild type and type I interferon receptor null Let1 cells. 27405392 2016
Entrez Id: 3600
Gene Symbol: IL15
IL15 		0.010 Biomarker disease BEFREE In oncolysis sensitive melanoma cells, delNS1-IL-15 (but not delNS1) infection resulted in the production of IL-15 levels ranging from 70 to 1140 pg/mL in the cell culture supernatants. 22563505 2012
Entrez Id: 5609
Gene Symbol: MAP2K7
MAP2K7 		0.010 Biomarker disease BEFREE Interference with MEK/ERK signalling by RNAi-mediated depletion or the MEK inhibitor U0126 did not affect the oncolytic effects of the delNS1 viruses. 22563505 2012
Entrez Id: 6655
Gene Symbol: SOS2
SOS2 		0.100 GeneticVariation disease CLINVAR Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome. 26173643 2015
Entrez Id: 6016
Gene Symbol: RIT1
RIT1 		0.100 CausalMutation disease CLINVAR
Entrez Id: 867
Gene Symbol: CBL
CBL 		0.100 CausalMutation disease CLINVAR
Entrez Id: 22800
Gene Symbol: RRAS2
RRAS2 		0.100 CausalMutation disease CLINVAR
Entrez Id: 1969
Gene Symbol: EPHA2
EPHA2 		0.300 Biomarker disease CTD_human Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid. 22845314 2012
Entrez Id: 8036
Gene Symbol: SHOC2
SHOC2 		0.300 Biomarker disease CTD_human Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. 19684605 2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.300 Biomarker disease CTD_human Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency. 17703371 2007
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.300 Biomarker disease CTD_human Germline gain-of-function mutations in RAF1 cause Noonan syndrome. 17603482 2007
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.300 Biomarker disease CTD_human Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene. 17468812 2007
Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2 		0.300 Biomarker disease CTD_human Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency. 17703371 2007
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.300 Biomarker disease CTD_human Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. 17603483 2007
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.400 Biomarker disease CTD_human A restricted spectrum of NRAS mutations causes Noonan syndrome. 19966803 2010
Entrez Id: 5894
Gene Symbol: RAF1
RAF1 		0.400 Biomarker disease CTD_human Germline gain-of-function mutations in RAF1 cause Noonan syndrome. 17603482 2007
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1 		0.400 Biomarker disease CTD_human Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency. 17703371 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.400 Biomarker disease CTD_human Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency. 17703371 2007
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		0.400 Biomarker disease CTD_human Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency. 17703371 2007
Entrez Id: 6654
Gene Symbol: SOS1
SOS1 		0.400 Biomarker disease CTD_human Germline gain-of-function mutations in RAF1 cause Noonan syndrome. 17603482 2007