|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also the role of HLA-DRB1 genotype has not been evaluated, though it's associated with fibrosis in autoimmune hepatitis.
|
27333038 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present findings suggest that the gene or genes conferring susceptibility to AIH lie in the region centromeric to the HLA A locus between HLA C and DRB1.
|
9328330 |
1997 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*12 was significantly more frequent in AIH patients with positive Hepatitis A IgM than in patients with negative hepatitis A IgM.
|
21067577 |
2010 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data indicate that type 1 AIH predisposition in a Venezuelan mestizo population of different ethnic backgrounds is associated with DRB1*1301 and DRB1*0301 alleles.
|
17927716 |
2007 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the DR4-specific sequence (Val 11 and His 13 at amino acid positions 11 and 13, respectively), but not particular Dw-associated DR4 sequence, in the first domain of the DRB1 chain contributes to susceptibility to autoimmune hepatitis among Japanese.
|
1350267 |
1992 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies of type 1 AIH have focused on the major histocompatibility complex (MHC), mapping susceptibility to the DRB1 region.
|
12447707 |
2002 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The principal HLA alleles associated with type 1 autoimmune hepatitis in Britain and North America are DRB1*0301 and DRB1*0401.
|
10807521 |
2000 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the HLA-DRB1*0403 allele differed among Japanese patients with AIH according to the presence or absence of anti-gAChR antibodies.
|
26807576 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 alleles of 76 children with pAILD (autoimmune hepatitis [AIH], autoimmune sclerosing cholangitis [AISC], primary sclerosing cholangitis [PSC]) and of 50 healthy blood donors as control group were analyzed retrospectively.
|
26567543 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In subtypes of DR4, there was a trend of increase in the gene frequency of DRB1 0405 in patients with AIH versus healthy controls (21.9% vs 6.3%, P=0.04, but P(c) =0.08).
|
11819862 |
2001 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CD4 T cells from patients with type 2 AIH positive for the predisposing HLA allele DRB1*0701 recognize seven regions of CYP2D6, five of which are also recognized by CD8 T cells.
|
18528928 |
2008 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genetic AIH risk factor HLA DRB1*03:01 was more frequent in younger patients, and DRB1*04:01 was more frequent in middle-aged patients without an obvious link to virus seropositivities.
|
30487523 |
2018 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA alleles appear to influence the exact phenotype-the most interesting apparent association being between HLA-DRB1*0301-DQB1*0201, liver-kidney microsome autoantibodies (anti-CYP1A2), and autoimmune hepatitis.
|
22344197 |
2012 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In 32 patients and 48 healthy controls, polymerase chain reaction amplified with sequence-specific primers (PCR-SSP) was performed to elucidate the relevance of certain alleles or polymorphic sequences of HLA-DRB1 with autoimmune hepatitis.
|
12519226 |
2003 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
American patients with type 1 autoimmune hepatitis had DRB1*03 alleles more commonly than the German patients with type 2 disease (51% vs 17%, p = 0.03) and DRB1*0301 occurred more frequently in the type 1 patients (51% vs 17%, p = 0.03).
|
9399751 |
1997 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1*03:01 was singly associated with AIH among whites (odds ratio [OR]: 3.09, P = 0.002) and carriers of DRB1*03:01 also carried DQA*05:01 and DQB1*02:01.
|
31211758 |
2019 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype.
|
7860360 |
1994 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*0405-DQB1*0401 haplotype in autoimmune pancreatitis showed no significant association with any HLA class I antigens, in contrast to the B54-DRB1*0405-DQB1*0401 haplotype reported in autoimmune hepatitis.
|
11984513 |
2002 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The C allele of rs7708392 was associated with AIH, especially AIH without DRB1*04:05, an already established risk factor.
|
29559739 |
2018 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1*0301 and DRB1*0401.
|
10613727 |
2000 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data provide evidence that specific residues in the DR beta polypeptides predispose to autoimmune hepatitis in white patients and genes linked to DRB3*0101 and DRB1*0401 may determine two clinically distinct disease patterns.
|
8119685 |
1994 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The most influential gene on type 1 AIH pathogenesis in Japanese is the HLA-DRB1.
|
15763345 |
2005 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1.
|
26693492 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two types of autoimmune hepatitis are justified by serological markers, but they also have distinctive genetic associations (DRB1 and DQB1 genes) and autoantigens.
|
25999246 |
2015 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, additional susceptibility genes (either HLA or non-HLA) and/or environmental factors may also contribute to the development of type 1 AIH; in Japanese type 1 AIH patients, although the most influential gene in disease susceptibility is HLA-DRB1*04:05, several other genes have been identified as being involved in AIH pathogenesis or resistance and are the currently the focus of single nucleotide polymorphism analysis.
|
20957499 |
2011 |